2023 Drug Metabolism Gordon Research Conference and Gordon Research Seminar

摘要 药物代谢领域的重点是定义和机械地理解吸收， 分子的分布、代谢和消除(ADME)性质。ADME拥有巨大的 对治疗分子和新方法的有效性、安全性和剂量的影响 和大分子，是今天和明天的药物之一。第51次药物代谢 GRC将重点关注ADME科学未来50年的挑战和机遇。重点 将讨论尖端科学和ADME学科之间相互联系的重要性，因此 我们充分挖掘新兴技术和新方法的潜力来发现， 开发和安全地使用来自不同模式的药物。这次会议将把 学术界、工业界和监管部门的科学家在职业生涯的所有阶段都提供了激励和 讨论未发表的研究并了解ADME面临的挑战的协作环境 不同的模式。药物代谢GRC的非正式会场提供了理想的环境 确立这一点。这次会议将为早期职业科学家提供一个论坛，以扩大他们的科学研究 广度，与该领域的领导者互动，建立未来的协作关系，并考虑 不同的职业道路。戈登研究研讨会将在GRC主要会议之前举行，提供 为学生和早期职业研究人员提供独特的环境来展示他们的工作，联系和拥有 有机会获得指导。与会者将接触到世界级演讲者的前沿演讲 鼓励新的想法和合作，重点关注多样性和连接性，以推动翻译 ADME科学，以便新的治疗和治疗可以更快地交付给患者。这些讲座是 在超过4.5天的时间里，在上午和晚上举行，下午可以进行非正式讨论 和娱乐。GRC会议规模较小，在两个正式会议期间都有更多的讨论时间 科学会议期间和非正式互动期间(例如，海报会议、用餐时间、下午郊游)。 为了便于有充分的机会讨论他们的工作，药物代谢GRC组织了四到两个小时的会议 海报会议，每名海报演示者(至少60人)可在两次会议期间进行讨论。

Abstract The field of Drug Metabolism is focused on defining and mechanistically understanding the Absorption, Distribution, Metabolism and Elimination (ADME) properties of a molecule. ADME has a tremendous influence on efficacy, safety, and dosing of therapeutic molecules and novel modalities, beyond small and large molecules, are amongst the medicines of today and tomorrow. The 51st Drug Metabolism GRC will focus on the challenges and opportunities of the next 50 years of ADME science. Emphasis will be on cutting-edge science and the importance of interconnectedness among ADME disciplines so that we fully tap into the potential of emerging technologies and novel approaches in discovering, developing, and safely using medicine from diverse modalities. The conference will bring together academic, industry and regulatory scientists at all career stages and provide a stimulating and collaborative environment to discuss unpublished research and learn about the ADME challenges of diverse modalities. The informal venue of the Drug Metabolism GRC provides an ideal environment to establish this. This conference will provide a forum for early career scientists to expand their scientific breadth, interact with leaders in the field, establish future collaborative relationships, and consider various career paths. A Gordon Research Seminar will precede the main GRC conference, providing a unique environment for students and early career researchers to present their work, connect and have access to mentoring. Attendees will be exposed to cutting edge presentations by world-class speakers to stimulate new ideas and collaborations with focus on diversity and connectivity driving translational ADME science so that new treatments and cures can be delivered to patients faster. The lectures are held in the mornings and evenings over 4.5 days with the afternoons available for informal discussions and recreation. GRC meetings are small and designed for more discussion time during both the formal scientific sessions and during informal interactions (e.g., poster sessions, mealtimes, afternoon outings). To facilitate ample opportunity to discuss their work, the Drug Metabolism GRC organizes four, two-hour poster sessions, with each poster presenter (at least 60) available for discussion during two sessions.