4D Visible Human Modeling for Radiation Dosimetry

描述（由申请人提供）： 辐射剂量学中的4D可视人体建模 我们提出了一个多学科的研究，以解决与病人呼吸运动的问题 在放射治疗期间，通过进一步将可视人体图像数据集扩展到具有运动模拟能力的第四维（4D）。放射治疗是治疗癌症最有效的方法之一。在外部射束放射治疗中，致命的放射剂量通过精确一致的外部放射递送到肿瘤，同时保留邻近的健康组织。然而，目前的范例是基于这样的假设，即肿瘤的位置和形状都是已知的，并且在辐射输送过程中保持不变。这种有利的刚体关系不存在于解剖部位，如胸腔和腹部，主要是由于呼吸运动。因此，放射肿瘤学家目前不得不使用具有大剂量裕度的较不积极的治疗策略来容忍潜在的靶向错误。我们建议开发基于物理学的运动模拟虚拟人体模型，这将为放射治疗期间的呼吸运动管理提供独特的见解，从而允许更积极和有效的靶向和辐射输送。组建了一个在辐射剂量学、生物力学建模和临床放射肿瘤学方面具有集体专业知识的多学科研究团队，以实现以下具体目标：1）将从高分辨率VHP冷冻切片图像数据开发的3D成人男性解剖模型与基于物理的组织变形模型结合联合收割机，以模拟呼吸运动。2.）的情况。为了将这第一个基于物理学的4D运动模拟虚拟人应用于使用先进的Monte Carlo模拟研究组织中复杂的辐射相互作用和各种辐射输送策略的剂量分布模式，3）为了严格评估内部器官的更真实表示将改善计划和输送治疗剂量的程度。（4）建立虚拟人体运动模拟和辐射剂量学的网络信息共享资源。

DESCRIPTION (provided by applicant): 4D Visible Human Modeling for Radiation Dosimetry We propose a multidisciplinary research to solve problems associated with patient respiratory motions during radiation therapy by further extending the Visible Human image dataset into the 4th dimension (4D) with motion-simulating capabilities. Radiation therapy is one of the most effective methods of cancer management. In external beam radiation treatment, a lethal radiation dose is delivered through precisely conformed external radiation to the tumor while sparing the adjacent healthy tissues. However, the current paradigm is based on an assumption that both the tumor location and shape are known and remain unchanged during the course of radiation delivery. Such a favorable rigid-body relationship does not exist in anatomical sites such as the thoracic cavity and the abdomen, owing predominantly to respiratory motions. Consequently, the radiation oncologists currently have to use less aggressive treatment strategies with a large dose margin to tolerate potential targeting errors. We propose to develop physics-based, motion-simulating virtual human models that will provide a unique insight into the management of respiratory motion during radiation treatment, thus allowing for more aggressive and effective targeting and radiation delivery. A multidisciplinary research team with collective expertise in radiation dosimetry, biomechanical modeling and clinical radiation oncology is assembled to achieve the following Specific Aims: 1) To combine the 3D adult male anatomical model developed from high-resolution VHP cryosection image data with physics-based tissue deformation models to simulate respiratory motions. 2.)To apply this first physics-based, 4D motion-simulating virtual-human to the study of complex radiation interactions in tissues and dose distribution patterns for various radiation delivery strategies using advanced Monte Carlo simulations, 3).To critically evaluate the degrees to which the more realistic representations of internal organs will improve the planned and delivered treatment doses. 4).To establish an internet-based information-sharing resource on virtual-human motion simulation and radiation dosimetry.