Continuation of Follow-up of DES-exposed Cohorts

我们的总体目标是1)跟踪达特茅斯的第二代和第三代队列，2)领导五个中心的第三代研究，以及3)领导和促进手稿开发。后续活动包括跟踪队列成员、发送问卷、进行电话采访、获得查阅病历的书面同意、检索病历以及向协调中心提交数据。我们还将领导第三代研究。大体上，这项责任包括维护第三代队列登记、监督数据收集和记录业务决策。我们将开发第三代研究相关材料，包括研究方案、问卷、病理摘要表和传递表。输入的数据将被输入电子文件、重复输入和验证。调查问卷和非答复表将与其他数据来源进行核对，包括队列登记和研究中心的进度报告。计算机化的数据将被编辑和清理，分析文件将被创建并分发到其他中心。我们还建议继续发挥我们在手稿开发方面的作用。目前，达特茅斯研究中心领导了三篇论文，涵盖了三代队列，后续数据成熟后将进行更多的论文。我们还将继续为其他研究中心发起的手稿做出贡献。

Our overall objectives are to 1) follow-up the second and third generation cohorts at Dartmouth, 2) lead the five-center third generation study, and 3) lead and contribute to manuscript development. Follow-up activities include tracing cohort members, sending questionnaires, conducting telephone interviews, obtaining written consent for medical record access, retrieving medical records, and submitting data to the coordinating center. We will also lead the third generation study. Broadly, this responsibility includes maintaining the third generation cohort registry, overseeing data collection, and documenting operational decisions. We will develop third generation study-related materials, including the study protocol, questionnaire, pathology abstraction forms, and transmittal forms. Incoming data will be entered into electronic files, double-entered, and verified. Questionnaires and non response forms will be reconciled with other data sources, including the cohort registry and the study centers' progress reports. The computerized data will be edited and cleaned, and analyses files will be created and distributed to other centers. We also propose to continue our role in manuscript development. Currently, the Dartmouth study center leads three papers, covering three generations of the cohorts, and additional papers will be undertaken when the follow-up data are mature. We will also continue to contribute to manuscripts initiated at the other study centers.