STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL

本合同的目标是为国家毒理学计划(NTP)的危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。该合同涉及通过灌胃和皮肤途径对5种化学品进行慢性和慢性研究，包括五溴二苯醚(DE-71)、吲哚-3-甲醇、甲基苯丙酮、季戊四醇三丙烯酸酯和三羟甲基丙烷三丙烯酸酯。季戊四醇三丙烯酸酯、五溴二苯醚和吲哚-3-甲醇的90天研究已经完成并报告。本合同取消了对季戊四醇三丙烯酸酯和吲哚-3甲醇的为期两年的研究。为期两年的甲基苯丙基酮和三羟甲基丙烷三丙烯酸酯研究的生活部分已经完成。对五溴二苯醚的慢性两年研究正在大鼠和小鼠身上进行。在五溴二苯醚慢性大鼠研究中，大鼠从怀孕第6天开始在子宫中接受治疗，一直持续到哺乳期，并将从青春期持续到成年。剂量将持续到大鼠两岁时，届时将对动物进行彻底的致癌迹象检查。 致癌性；毒性；Wistar汉族大鼠；Fisher大鼠；B6C3F1小鼠；围产期；三丙烯酸酯；阻燃剂；五溴联苯氧化物；DE-71；吲哚-3-甲醇；甲基苯丙基酮；季戊四醇三丙烯酸酯；三羟甲基丙烷三丙烯酸酯。

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. This contract involes the prechronic and chronic studies of 5 chemicals by gavage and dermal routes including Pentabromodiphenyl oxide (DE-71); Indole-3-carbinol; Methyl styryl ketone; Pentaerythritol triacrylate; and Trimethylolpropane triacrylate. The 90-Day studies of Pentaerythritol triacrylate, Pentabromodiphenyl oxide and Indole-3-carbinol have been completed and reported. The 2-year studies for Pentaerythritol triacrylate and Indole-3 carbinol have been cancelled from this contract. The in-life portion of the 2-year Methyl styryl ketone and Trimethylolpropane triacrylate studies have been completed. Chronic 2 year studies on Pentabromodiphenyl oxide are ongoing in rats and mice. In the Pentabromodiphenyl oxide chronic rat study, rats have been treated in utero beginning on gestation day 6, continuing through the lactation period and will be continuously treated through puberty to adulthood. Dosing will continue until rats are two years of age at which time animals will be thoroughly examined for signs of carcinogenicity. Keywords Carcinogenicty; Toxicity; Wistar Han rats; Fisher rats; B6C3F1 mice; perinatal; triacrylates, flame retardants; Pentabromodiphenyl oxide; DE-71; Indole-3-carbinol; Methyl styryl ketone; Pentaerythritol triacrylate; and Trimethylolpropane triacrylate.