BrainVision BrainAmp MR Plus

描述(申请人提供)：目前，由西奈山医学院神经成像实验室进行和支持的功能神经成像研究使用功能磁共振作为主要测量手段。功能磁共振成像是功能神经成像技术中空间分辨率的标志，能够分辨出相隔几毫米的激活簇。然而，它的时间分辨率在几秒钟的量级上。FMRI的时间分辨率不仅取决于采样间隔，还受内在生物因素的影响。因此，不可能解决彼此在一秒内发生的事件。一种理想的功能磁共振互补成像技术应该能够以毫秒级的时间分辨率测量活动的变化，而脑电(EEG)或事件相关电位(ERPs)等电生理指标已被证明非常适合这一角色。目前的提案旨在购买与核磁共振兼容的脑电/事件相关电位记录系统，以便用高时间分辨率的电生理数据补充功能核磁共振数据，以扩大可利用西奈山医学院神经成像实验室现有资源进行检验的假设范围。这一资源的增加将促进认知功能模型的开发和测试，这些模型纳入了为这些功能服务的网络的时间动态的因素。除了购买这一系统，我们还建议建立一个不偏不倚的当地咨询委员会，该委员会将监督这一资源的管理，以确保它继续吸引新用户，并确保NIH资助的项目获得与目标科目注册和项目时间表相称的资源的比率。购买这种设备与公众健康直接相关，因为它将促进我们对各种精神疾病的神经基础的了解。在NIH资助的调查自闭症、双相情感障碍和注意力缺陷/多动障碍的各个方面的项目中，详细讨论了新仪器的使用，并提出了仪器将允许测试的特定假设。随着西奈山研究基础设施的积极扩展，重点放在临床研究上，预计NIH资助的研究人员在未来几年对这一核心的利用将继续增长。与公共健康相关：这项提议的目的是购买设备，使研究人员能够以高时间分辨率调查大脑中离散结构的激活时间过程，这是使用目前可用的资源无法实现的。购买这种设备将使NIH资助的几名研究人员受益，这些研究人员正在进行包括自闭症、双相情感障碍和注意力缺陷/多动障碍在内的精神障碍的各个方面的研究。

DESCRIPTION (provided by applicant): Currently, the functional neuroimaging research conducted and supported by the Laboratory of Neuroimaging at the Mount Sinai School of Medicine utilizes fMRI as a primary measure. fMRI is the hallmark of spatial resolution amongst functional neuroimaging techniques, capable of resolving clusters of activation millimeters apart. However, its temporal resolution is on the order of several seconds. The temporal resolution of fMRI is determined not only by sampling interval but also by intrinsic biological factors. Therefore it is not possible to resolve events occurring within as much as one second of each other. An ideal complementary imaging technique for fMRI would have the ability to measure changes in activity with a temporal resolution on the order of milliseconds, and electrophysiological measures such as the electroencephalogram (EEG) or event related potentials (ERPs) have proven to fit this role perfectly. The current proposal aims to purchase an MRI-compatible EEG/ERP recording system in order to supplement fMRI data with high-temporal resolution electrophysiological data in order to expand the scope of hypotheses that are testable using the resources available through the Laboratory of Neuroimaging, a core functional neuroimaging resource of the Mount Sinai School of Medicine. Addition of this resource will facilitate development and testing of models of cognitive function that incorporate factors accounting for the temporal dynamics of networks subserving these functions. In addition to purchase of this system, we also propose the establishment of an unbiased local advisory committee who will oversee the administration of this resource to ensure that it continues to attract new users and that NIH funded projects are given rates of access to the resource commensurate with targeted subject enrollment and project timelines. Purchase of this equipment has direct relevance to public health because it will advance our knowledge of the neural underpinnings of various psychiatric disorders. Use of the new instrumentation in NIH funded projects investigating various aspects of autism, bipolar disorder, and attention deficit/hyperactivity disorder is discussed in detail with specific hypotheses that the instrumentation will permit testing of. With active expansion of the research infrastructure at Mount Sinai with a focus on clinically oriented research, it is expected that utilization of this core by NIH funded researchers will continue to grow over the next several years. PUBLIC HEALTH RELEVANCE: The aim of this proposal is to purchase equipment that will allow researchers to investigate the time course of activation of discrete structures in the brain with high temporal resolution, which is not possible using currently available resources. Purchase of this equipment will benefit several NIH-funded researchers conducting studies on various aspects of psychiatric disorders including autism, bipolar disorder, and attention deficit/hyperactivity disorder.