Career Development and Mentoring in Clinical/Translational Alcohol Research

描述(由申请者提供)：高级科学家研究和导师奖面向“在生物医学研究中证明了持续水平的高生产率的杰出资深科学家”，以保护他们继续研究的时间，同时指导下一代研究人员。拥有20多年的临床酒精研究经验[20多项临床试验、渴求(OCDs)、饮酒生物标记物(CDT)和神经成像]，15年R01持续资助，12年担任酒精研究中心科学主任，180篇同行评议的出版物和国际认可，候选人符合作为一名杰出高级科学家的要求。他曾被选为领先的学术和研究学会的高级领导职位，担任指导委员会的同行选举主席，领导由NIH/NIAAA资助的大型多中心临床试验(联合研究)，该试验研究了1383名酒精依赖者，并因其弥合基础研究和临床研究之间差距的独特技能、知识和能力而被视为专家。他在保持积极的酒精研究培训计划的同时完成了这一目标，包括担任NIAAA赞助的T32研究培训基金的主任或联席主任20年。他已经指导了17名专业人士(12名医学博士和5名博士)，许多人因为他在基础和临床科学方面的专业知识而找到他，许多人获得了独立的酒精研究资金，以及所有仍然与酒精领域联系在一起的人。他对酒精障碍治疗的机制和应用的理解是非典型的和例外的。这个奖项对候选人来说很重要，主要有两个原因：首先，它将为他提供保护的时间，使他能够通过获得遗传学和蛋白质组学(职业生涯计划中提供的课程细节)的正式和非正式培训，将这些基本科学领域应用到他自己的酒精研究中，并向酒精治疗领域总体交流新发现，从而使他的酒精研究生涯保持在前沿。其次，该奖项将为候选人提供保护时间，使其免于承担额外的临床和行政职责，以便他可以继续并扩大他的积极指导计划，该计划专注于下一代临床科学家的发展。他从培训中学到的知识和技能将融入并加强他的指导计划。随着美国医学研究所和美国医学院协会强调美国对临床和翻译研究人员的大量未得到满足的需求，以及数百万患有酒精障碍的美国人，他们得不到服务，每年给美国经济造成1800亿美元的损失，因此有必要推动临床研究，需要确保我们的资深科学家处于研究的前沿，需要培训未来的科学家来进行这项研究，以找到有效的治疗方法。K05高级科学家职业生涯和导师奖将使这一目标得以实现。

DESCRIPTION (provided by applicant): The Senior Scientist Research and Mentorship Award is targeted for "outstanding senior scientists who have demonstrated a sustained level of high productivity conducting biomedical research" in order to protect their time to continue research while mentoring the next generation of investigators. With more than 20 years of experience in clinical alcohol research [over 20 clinical trials, seminal work in craving (OCDS), biomarkers of drinking (CDT), and neuroimaging], 15 years of continued R01 funding, 12 years of serving as Scientific Director of an Alcohol Research Center, 180 peer reviewed publications, and international recognition, the candidate meets the requirements as an outstanding senior scientist. He has been elected to high leadership positions of leading academic and research societies, serves as the peer-elected chairman of the steering committee, directing the large, multi-center NIH/NIAAA funded clinical trial (COMBINE Study) which studied 1383 alcohol dependent individuals, and is sought out as an expert for his unique skill set, knowledge and ability to bridge the gap between basic and clinical research. He has accomplished this while maintaining an active training program in alcohol research, including 20 years as Director or Co-Director of an NIAAA-sponsored T32 Research Training Grant. He has mentored 17 professionals (12 MDs & 5 PhDs), many who sought him out due to his expertise in bridging basic and clinical science, many who have secured independent alcohol research funding, and all who remain tied to the alcohol field. His understanding of both the mechanisms of, and applications to, the treatment of alcohol disorders is atypical and exceptional. This award is important to the candidate for two major reasons: First, it will provide him with protected time to keep his alcohol research career on the cutting edge by enabling him to obtain formal and informal training in genetics and proteomics (course details provided in the career plan), apply these essential areas of science to his own alcohol research (as outlined), and communicate new discoveries to the alcohol treatment field in general. Second, this award will provide the candidate with protected time from additional clinical and administrative duties so he can continue with and expand his active mentoring program which is focused on the development of the next generation of clinical scientists. The knowledge and skills he gains from his training will be integrated into and strengthen his mentoring program. With the Institute of Medicine and the American Association of Medical Colleges highlighting the large, unmet need in the US for clinical and translational researchers and with millions of Americans suffering from alcohol disorders, who are underserved and who cost the US economy $180 billion each year, there is a need to push clinical research forward, a need to ensure our senior scientists are on the cutting edge in their research, and a need to train future scientists to carry on this research to find effective treatments. This K05 Senior Scientist Career and Mentoring Award will allow this to happen.