Cellular and Molecular Biology at Michigan

描述(由申请人提供)：密歇根大学的细胞和分子生物学(CMB)项目是拉克姆研究生院三十多年来独立的博士学位授予项目。这个项目的目的是培养学生在细胞和分子生物科学方面具有广阔的视角。它是密歇根州最受欢迎的生物医学研究生课程之一，在过去的5年里，有78名新学生进入该项目，另外44人获得了博士学位。全大学的CMB计划利用了医学院、牙科学院、工程学院和文学与艺术学院的23个系的教员、课程和研究设施。这种专业知识和机会的多样性使学生在选修课程和强大的研究培训环境方面有了尽可能广泛的选择。与此同时，该计划的学生通过灵活的必修和选修课程计划、强有力的学生研讨会计划、学生组织的短期课程、年度研讨会和海报会议、研究论坛、社交活动和对该计划的服务，分享核心的共同培训经验。CMB的活动为该计划提供了凝聚力，并为大学的智力环境做出了贡献，因为它受到高度重视和大量参与的科学活动。CMB 108名教职员工的实验室研究项目涵盖了广泛的学科，包括：遗传学、基因组学、基因调控；细胞生物学、生物化学、生理学和结构；微生物发病机制；免疫学；发育生物学、神经生物学、衰老；分子机制和疾病遗传学。CMB计划是该大学唯一提供不同问题和视角培训的实体，鼓励对基础和转化性生物医学研究采取跨学科方法。CMB项目的持续增长反映了人们对其跨学科方法的日益浓厚的兴趣，并突显了该项目在该大学生物医学科学项目中的独特作用。该提案要求支持20名受训人员，目标是在两年内每年支持10名学生。目前的目标是保持招商银行计划的活力，同时保留招商银行以高质量和个性化而闻名的培训。相关性：CMB项目的学生直接研究基础和临床科学中的问题，这些问题对一系列公共卫生问题具有重要影响，包括癌症、慢性(例如糖尿病、类风湿性关节炎)、传染性(例如艾滋病、分枝杆菌)和神经退行性疾病(例如帕金森氏症、阿尔茨海默氏症)。此外，培训将细胞和分子方法应用于各种科学学科的学生继续增加学术和应用研究领域的杰出科学家的人数，他们的工作促进了对人类健康重要的广泛领域的知识。

DESCRIPTION (provided by applicant): The Cellular and Molecular Biology (CMB) Program at the University of Michigan has been a free-standing Ph.D. degree-granting program of the Rackham School of Graduate Studies for over thirty years. The aim of this program is to train students with a broad perspective in cellular and molecular biosciences. It is one of the most popular graduate programs in biomedical sciences at Michigan, and during the past 5 years, 78 new students entered the Program and 44 others received Ph.D. degrees. The University-wide CMB Program draws on faculty, courses and research facilities from 23 departments in the Schools of Medicine, Dentistry, Engineering and the College of Literature Sciences and the Arts. This diversity of expertise and opportunity allows students the broadest possible choice in terms of both elective coursework and strong research training environments. At the same time, students in the Program share a core of common training experiences through a flexible program of required and elective coursework, a strong student seminar program, student-organized short courses, an annual symposium and poster session, a research forum, social events and service to the Program. CMB events provide cohesiveness for the Program and contribute to the intellectual environment of the University as highly regarded and well-attended scientific activities. Research programs in the laboratories of the 108 faculty members in CMB cover a wide range of disciplines, including: genetics, genomics, gene regulation; cell biology, biochemistry, physiology and structure; microbial pathogenesis; immunology; developmental biology, neurobiology, aging; molecular mechanisms and genetics of disease. The CMB Program is the only entity at the University that provides training in such diverse problems and perspectives, encouraging interdisciplinary approaches to both basic and translational biomedical research. The continuing growth of the CMB Program reflects increasing interest in its interdisciplinary approach, and highlights its unique role in the context of the Program in Biomedical Sciences at the University. This proposal requests support for 20 trainees, with the aim of supporting 10 students per year for two years. The current goal is to maintain the vitality of the CMB Program while retaining the high quality and individualized training for which CMB is known. Relevance: The research performed by students in the CMB Program directly addresses problems in both fundamental and clinical sciences that have important implications for a broad array of public health problems, including cancer, chronic (e.g. diabetes, rheumatoid arthritis), infectious (e.g. AIDS, mycobacterial) and neurodegenerative (e.g. Parkinson's, Alzheimer's) diseases. Further, training students who apply cellular and molecular approaches to a wide variety of scientific disciplines continues to add to the population of outstanding scientists in academic and applied research whose work advances knowledge in a wide range of areas important for human health.