Cancer Center Support Grant

描述（由申请人提供）：这是范德比尔特-英格拉姆癌症中心（VICC）CCSG的第二个竞争性继续申请。 VICC是范德比尔特大学医学中心（VUMC）内的矩阵中心，VICC整合了医学院，护理学院，艺术与科学学院，工程学院和皮博迪教育学院以及完全整合的退伍军人管理局医疗中心（VAMC）的癌症相关专业知识和资源。 所有设施都位于同一个校园，促进互动，资源共享和协作的情况。 维也纳国际中心成立于1993年，是一个具有超部门地位的组织单位。 VICC的具体权力和职责是：1）进行协调和整合范德比尔特大学的癌症和癌症相关活动; 2）进行，支持和加强癌症研究，并在整个大学整合癌症相关活动; 3）整合，开发和开展癌症教育计划;和4）协调和整合VUMC和VAMC癌症患者的护理。 研究目标是通过七个研究项目来实现的，这些项目与之前的申请基本相同，只是名称略有变化。 这些方案是：信号转导和细胞增殖，癌症蛋白质组学和基因组学，宿主-肿瘤相互作用，胃肠道癌，乳腺癌，癌症预防和基于人群的研究，以及实验治疗。 拟议的16项共享资源包括8项以前得到支助的资源和8项新资源。 在过去的项目期间，国际中心的发展取得了显著进展。 该中心已更名为范德比尔特-英格拉姆癌症中心，这是基于英格拉姆家族发起的资本运动所承诺的大量慈善资金。 从资本运动的资金已与机构资金杠杆招募80名新教师加强所有的VICC研究计划，建立20个捐赠的教授职位招聘和保留，扩大空间控制和利用的VICC，并建立尖端的基因组，蛋白质组学和信息学共享资源。 通过招募12名癌症流行病学家，建立了一个大型的基于人群的研究计划，他们现在领导着三个新资助的主要队列，分别位于VICC，南方社区队列，女性上海队列和男性上海队列。 三个NCI SPORE赠款已经获得资助，自上次更新以来，VICC的NCI资金基础增加了2.9倍。

DESCRIPTION (provided by applicant): This is the second competing continuation application for the Vanderbilt-Ingram Cancer Center (VICC) CCSG. The VICC is a matrix center within Vanderbilt University Medical Center (VUMC), and the VICC integrates the cancer-related expertise and resources of the School of Medicine, School of Nursing, School of Arts and Sciences, School of Engineering, and Peabody School of Education as well as the fully integrated Veterans Administration Medical Center (VAMC). All facilities are located on the same campus, a situation that promotes interactions, sharing of resources, and collaborations. Established in 1993, the VICC functions as an organizational unit with a supradepartmental status. The VICC's specific authorities and responsibilities are: 1) to conduct coordinate and integrate the cancer and cancer-related activities of Vanderbilt University; 2) to conduct, support and enhance cancer research and to integrate cancer-related activities throughout the University; 3) to integrate, develop and conduct cancer education programs; and 4) to coordinate and integrate the care of cancer patients at VUMC and VAMC. The research objectives are accomplished through seven Research Programs that are essentially the same as in the previous application with minor name changes. The Programs are: Signal Transduction and Cell Proliferation, Cancer Proteomics and Genomics, Host-Tumor Interactions, Gastrointestinal Cancer, Breast Cancer, Cancer Prevention and Population-Based Research, and Experimental Therapeutics. Sixteen Shared Resources are proposed representing eight previously supported and eight new. There has been remarkable progress in the development of the VICC over the past project period. The Center has been renamed the Vanderbilt-Ingram Cancer Center based on a substantial commitment of philanthropic funds from the Ingram family that initiated a capital campaign. Funds from the capital campaign have been leveraged with Institutional funds to recruit 80 new faculty enhancing all of the VICC Research Programs, establish 20 endowed professorships for recruitment and retention, expand space controlled and utilized by the VICC, and establish cutting-edge genomic, proteomic and informatics shared resources. A large population-based research initiative was established through recruitment of 12 cancer epidemiologists who now head three newly funded major cohorts based at the VICC, the Southern Community Cohort, the Women's Shanghai Cohort, and the Men's Shanghai Cohort. Three NCI SPORE grants have been funded, and the NCI funding base for the VICC has increased 2.9 fold since the last renewal.