Center of Excellence in Environmental Toxicology

这是一个修订后的申请，以建立一个NIEHS中心的环境健康科学在 宾夕法尼亚大学。该中心将举行的标题：“中心卓越的环境 毒理学（CEET）”这将是一个单一的实体，协调，促进，协同和整合所有 环境相关的健康研究和推广在大学。CEET已经确定了50个 来自5所学校16个部门的教师作为中心成员。这些成员致力于CEET 使命是：改善生活在工业老化的城市环境中的公众的健康 基础设施，通过基础，转化和临床研究，以及推广。他们将与 环境暴露，分子/细胞效应，健康结果， 通过有效的预防或干预策略， 和/或环境政策的变化。该使命将通过四项综合研究来完成 核心，三个设施核心和一个充满活力的社区外展和教育计划（COEP）。的 研究核心由具有国际声誉的研究人员领导。这些核心处于氧化状态 应激和氧化应激损伤（联合主任：布莱尔博士和伊坎罗普洛斯），内分泌和生殖 干扰（联合主任：Strauss博士和曼森）、肺部和气道疾病（联合主任：Panettieri博士 和Albedla），基因与环境（联合主任：Rebeck博士和Whitehead）。这些核 解决对我们城市地区很重要的环境卫生问题。不良生殖和妊娠 结果，发育障碍，以及肺部和气道疾病是常见的，并解决 在以器官为基础的核心中。《氧化应激》和《环境中的基因》中的核心内容将阐明关键机制 环境暴露可导致这些和其他器官系统的毒性 形成一个综合的中心结构。设施核心将在毒理基因组学，毒理蛋白质组学 和生物标志物，并将为研究者提供服务，否则将无法实现， 推动研究人员进入预测毒理学的新时代。COEP将传播研究成果 调查结果和利用CEET调查人员的专业知识：加强K-16环境教育 健康;在宾夕法尼亚州东南部四个面临环境挑战的地区开展社区外展活动 社区，并丰富卫生保健专业人员的教育。COEP已经建立了关系 与社区合作伙伴进行外联。COEP的目标是减少有害暴露的风险， 改善这些社区内弱势群体的公共卫生。

This is a revised application to establish a NIEHS Center in Environmental Health Sciences at the University of Pennsylvania. The Center will hold the title: "Center for Excellence in Environmental Toxicology (CEET)" It will be the single entity that coordinates, facilitates, synergizes and integrates all environmentally related health research and outreach at the University. The CEET has identified 50 faculty in 16 departments from 5 Schools as Center members. These members are dedicated to the CEET mission which is: to improve the health of the public living in urban environments with an aging industrial infrastructure, through basic, translational and clinical research, and outreach. They will relate environmental exposures, to molecular/cellular effects, to health outcomes, with the vision that diseases with environmental etiology can be largely eliminated by effective prevention or intervention strategies and/or changes in environmental policy. The mission will be accomplished via four integrated Research Cores, three Facility Cores and a vibrant Community Outreach and Education Program (COEP). The Research Cores are led by investigators with international reputations. These Cores are in Oxidative Stress and Oxidative Stress Injury (Co-Directors: Dr. Blair & Ischiropoulos), Endocrine and Reproduction Disruption (Co-Directors: Dr. Strauss and Manson), Lung and Airway Disease (Co-Directors: Dr. Panettieri and Albedla), and Genes and the Environment (Co-Directors: Dr. Rebbeck and Whitehead). These cores address environmental health issues important to our urban region. Adverse reproductive and pregnancy outcomes, developmental disorders, and diseases of the lung and airway are common, and are addressed in the organ-based cores. The cores in Oxidative Stress and Genes in the Environment will elucidate keymechanisms by which environmental exposures can lead to toxicity in these and other organ systems leading to an integrated Center structure. The Facility Cores will be in Toxicogenomics, Toxicoproteomics and Biomarkers, and will provide investigators with services that would otherwise be unattainable and will propel investigators into the new era of predictive toxicology. The COEP will disseminate the research findings and utilize the expertise of CEET investigators: to enhance K-16 education in environmental health; to conduct community outreach in four environmentally challenged Southeastern Pennsylvania communities, and to enrich the education of health care professionals. The COEP has forged relationships with community partners for outreach. The COEP goal will be to reduce the risk of harmful exposures and improve the public health of vulnerable populations within these communities.