Clinical

临床核心的目标是通过以下方式提高CWRU和合作中心的艾滋病研究质量 实现以下具体目标： 1.维护和扩展一个全面和可访问的患者护理数据库（SIU数据库）， 促进临床管理，并作为临床研究的强大资源。 2.维护和扩展与患者护理数据库相链接的标本库， 随时访问与全面的患者护理数据集相关联的存储样本。 3.利用用户友好的SIU数据库的资源，临床研究协调员为研究人员提供 访问预先选择的感兴趣患者并确定为合格（通过审查SIU数据库）， 通过临床试验或其他研究参与HIV临床研究。 该核心的目标是促进临床和转化研究。该核心的三个关键资源有助于 通过无缝和快速访问临床信息和临床材料，开展研究活动。这个临床核心是 在艾滋病毒研究机构中，为临床样本提供全面和方便的访问， 感兴趣的患者和容易获得的临床数据。CFAR临床核心包括三个相互关联的关键 资源：CWRU/UHC CFAR SIU数据库，SIU标本库;和临床研究访问协调。 在今后一段时期，这一核心努力： * 与联合国合作，测试将数据库资源扩展到其他发展中国家的可行性。 CWRU/UHC乌干达实验室核心和流行病学生物统计学核心，建立CFAR 数据库在乌干达的坎帕拉。该项目还将包括培训工作人员和调查员。 增加CWRU/UHC CFAR调查员以及其他CFAR和外部机构的调查员人数 他们将通过扩大外展来利用CFAR临床核心资源。 帮助建立和领导CFAR协作C-NICS项目，该项目目前正在建立一个大型的集中式 数据库和6个CFAR研究中心的前瞻性队列。 ●扩大可冷冻保存的PBMC的储存库，以包括从所有人获得的样本的年度储存 知情同意的特别调查组病人

The goals of the Clinical Core are to enhance the quality of AIDS research at CWRU and at collaborating centers by achieving the following specific aims: 1. Maintaining and expanding a comprehensive and accessible patient care database (the SIU database) that both facilitates clinical management and serves as a robust resource for clinical investigation. 2. Maintaining and expanding a specimen repository linked to the patient care database that provides researchers ready access to stored samples linked to a comprehensive patient care data set. 3. Capitalizing on the resources of the user-friendly SIU database, a clinical studies coordinator provides researchers access to patients pre-selected for interest and identified as eligible (through review of the SIU database) to participate in HIV clinical research through clinical trials or other research studies. The goal of this core is to facilitate clinical and translational research. The three key resources of this core facilitate research activities through seamless and rapid access to clinical information and clinical material. This clinical core is remarkable among HIV research facilities for the comprehensive and ready access that is provided to clinical samples, to interested patients and to readily accessible clinical data. The CFAR Clinical Core comprises three key, interrelated resources: CWRU/UHC CFAR SIU database, SIU specimen repository; and clinical studies access coordination. In the coming period, this core seeks to: ¿ Test the feasibility of expanding the database resource to other developing nations in collaboration with the CWRU/UHC Ugandan Laboratory Core and the Epidemiology Biostatistics Core by establishing the CFAR Database in Kampala, Uganda. This project will also include the training of staff and investigators. ¿ Increase the number of CWRU/UHC CFAR investigators and investigators at other CFARS and outside institutions who will utilize CFAR Clinical Core Resources through expanded outreach. ¿ Help to build and lead the CFAR collaborative C-NICS project which is presently establishing a large centralized database and prospective cohort at 6 CFAR sites. ¿ Expand the repository of viably cryopreserved PBMC to include annual storage of samples obtained from all consenting SIU patients.