CORE CENTER

描述(由申请者提供)：Boys town国立研究医院(BTNRH)核心中心将在三个领域提供核心支持：(1)实验室计算；(2)转基因小鼠模型的使用；(3)人类研究对象的招募。在斯蒂芬·尼利的领导下，实验室计算核心(LCC)将开发供多个实验室使用的数据收集软件的通用版本，开发和维护PLT等通用软件工具，开发和维护专用数据库软件，协助调查人员安装、校准和维护硬件，并为中断数据收集的问题提供故障排除。由Dominic Cosgrove和JoAnn McGee领导的转基因小鼠模型核心(TMMC)将在畜牧业领域提供升级服务，以保持特定的无病原体动物护理设施，支持动物资源共享，并将为转基因和基因敲除小鼠的基因分型提供服务和支持。在Michael Gorga的指导下，人类研究主题核心(HRSC)将为研究人员提供接触到已表示有兴趣参与研究的潜在受试者的机会，开展具体活动以增加BTNRH研究计划中少数群体的代表性，并将更多信息纳入人类受试者数据库，使其成为研究人员进行与言语和语言正常和异常发展相关的研究的更有效工具。核心中心目前的用户群包括9个R01赠款，还有一些其他申请有待审查。以下关键人员名单包括16名高级工作人员，他们要么担任符合条件的R01的首席调查员或联合调查员，要么可能在核心中心的五年周期内加入用户群。

DESCRIPTION (provided by applicant): The Boys Town National Research Hospital (BTNRH) Core Center will provide core support in three areas: (1) Laboratory Computing; (2) use of Transgenic Mouse Models; and (3) recruitment of Human Research Subjects. The Laboratory Computing Core (LCC), under the direction of Stephen Neely, will develop general versions of data collection software for use in multiple laboratories, develop and maintain generally useful software tools such as PLT, develop and maintain special-purpose database software, provide assistance to investigators on the installation, calibration and maintenance of hardware, and provide troubleshooting for problems that interrupt data collection. The Transgenic Mouse Models Core (TMMC), under the direction of Dominic Cosgrove and JoAnn McGee, will provide upgraded services in the area of animal husbandry to maintain a specific pathogen-free Animal Care Facility that supports the sharing of animal resources and will provide service and support for the genetic typing of transgenic and knockout mice. The Human Research Subjects Core (HRSC), under the direction of Michael Gorga, will provide investigators access to a pool of potential subjects who have indicated an interest in participating in research, carry out specific activities to increase the representation of minority populations in research programs at BTNRH and incorporate additional information into the human subjects database to make it a more effective tool for investigators conducting studies related to normal and abnormal development of speech and language. The current user base for the Core Center includes nine R01 grants, with a number of other applications pending review. The list of key personnel below includes 16 senior staff members who either serve as principal investigators or co-investigators of the qualifying R01s or who are likely to join the user base during the five-year cycle of the Core Center.