UAB Diabetes Research and Training Center

总体描述（由申请人提供）： 该提案将在伯明翰的亚拉巴马大学（UAB）建立一个新的糖尿病研究和培训中心（DRTC）。该中心的近期目标是促进糖尿病研究的卓越。通过这些努力，该中心最终致力于降低发病率/死亡率，提高我们的糖尿病患者的生活质量，并为学生培训和教师在糖尿病研究中的职业发展提供一个良好的环境。我们的具体目标是： 1.通过建立研究者明确要求的核心技术，促进和加强糖尿病研究。这些技术将由三个生物医学资源核心（生物分析氧化还原生物学，动物生理学和人类生物学核心）和两个预防和控制核心（生物学和卫生服务研究和社区参与核心）有效提供。 2.通过试点和可行性资助计划加强糖尿病研究，该计划将强调极具前途的初级研究人员的创新，翻译和职业发展。 3.促进一个有凝聚力的知识环境，为优秀的多学科研究人员基地，这将加强学习，协作，合议和创新。 4.开发和评估糖尿病患者护理的新模式，包括多学科医疗保健团队，以改善患者的治疗效果，为临床培训提供场所，并为转化和医疗服务提供研究创建实验室。 5.利用UAB领导层的决心，大量的机构承诺，以及我们社区的慷慨慈善事业，推动在南方腹地发展卓越的糖尿病研究中心。 一个新的DRTC将对UAB的糖尿病研究产生很大的影响，原因有几个，包括（i）我们的患者在美国糖尿病发病率最高，（ii）UAB研究中心提供的合作和培育环境，最重要的是，（iii）在人类生理学，动物生理学，自由基生物学和氧化应激，炎症，血管生物学、健康差异、卫生服务和社区研究。糖尿病既是一种代谢性疾病，也是一种血管性疾病，DRTC采用的一种策略是围绕这些共同主题联合代谢和血管研究人员，以更好地了解糖尿病、糖尿病并发症和心脏代谢风险的机制、预防和控制。

DESCRIPTION, OVERALL (provided by applicant): This proposal will establish a new Diabetes Research and Training Center (DRTC) at the University of Alabama at Birmingham (UAB). The immediate goal of the center is to promote excellence in diabetes research. Through these efforts, the center ultimately endeavors to decrease morbidity/mortality and increase quality of life for our diabetes patients, and to provide an outstanding environment for student training and for faculty career development in diabetes research. Our specific aims are to: 1. Facilitate and enhance diabetes research by establishing core technologies expressly required by our investigator base. These technologies will be effectively provided by three biomedical resource cores, Bioanalytical Redox Biology, Animal Physiology, and Human Biology Cores, and two Prevention & Control cores, the Metrics & Health Services Research and Community Engagement Cores. 2. Augment diabetes research via a pilot & feasibility grant program that will emphasize innovation, translation, and career development of highly promising junior investigators. 3. Promote a cohesive intellectual environment for an outstanding multi-disciplinary investigator base, which will enhance learning, collaboration, collegiality, and innovation. 4. Develop and evaluate new models of diabetes patient care that incorporate multi-disciplinary health care teams to improve patient outcomes, provide venues for clinical training, and create laboratories for translational and health services delivery research. 5. Leverage the resolve of UAB leadership, substantial institutional commitments, and generous philanthropy from our community to impel the development of a pre-eminent center of diabetes research excellence in the heart of the deep south. A new DRTC will have a high impact for diabetes research at UAB for several reasons including (i) our patients who have the highest rates of diabetes in the US, (ii) the collaborative and nurturing environment afforded research centers at UAB, and, most importantly, (iii) an outstanding investigator base with diabetes research excellence in human physiology, animal physiology, free radical biology and oxidative stress, inflammation, vascular biology, health disparities, health services, and community based research. Diabetes is both a metabolic and vascular disease, and one strategy employed by the DRTC is to unite metabolic and vascular researchers around these common themes to achieve a better understanding of the mechanisms, prevention, and control of diabetes, diabetes complications, and cardiometabolic risk.