New Asymmetric Transformations and Chemical Synthesis of Natural Products

该研究计划旨在开发新的和有效的方法制备复合物 生物活性有机分子。K99指导阶段提出的研究将在1-2年内进行， 与Larry Overman教授合作多年，涉及新的不对称Pd（II）催化反应的发现 烯丙基三氯乙酰亚胺酯在制定这一方法之前，将在 在高效合成微叶醌的背景下，微叶醌是一种小分子， 几种细胞系。ROO独立阶段（3-5年）将重点关注发现不对称的 金属介导的偶联反应，以促进形成全碳四元立构中心， 复杂分子合成中经常遇到的挑战。这一强大的方法论将扩展到 包括用于快速构建对映体富集的稠合和双环体系的级联反应 从简单的前手性原料开始。最后，我们还研究了两个强有力的 将继续研究化合物芒果酚A和C。 如果该提案的目标得以实现， 分子将被开发。最终，这一贡献将促进新药物的发现 用于治疗人类疾病

This research program aims to develop new and efficient methods for the preparation of complex bioactive organic molecules. Research proposed in the K99 Mentored phase will be carried out over 1-2 years with Professor Larry Overman and involve the discovery of new asymmetric Pd(ll)-catalyzed reactions of allylic trichloroacetimidates. Pending the development of this methodology, it will be evaluated in the context of an efficient synthesis of microphyllaquinone, a small molecule that exhibits cytotoxicity against several cell lines. The ROO Independent phase (years 3-5) will focus on the discovery of an asymmetric metal-mediated coupling reaction to promote the formation of all-carbon quaternary stereocenters, a challenge often encountered in complex molecule synthesis. This powerful methodology will be expanded to include cascade reactions for the rapid construction of enantioenriched fused and bicyclic ring systems beginning from simple, prochiral starting materials. Finally, the asymmetric total syntheses of two potent antiinflammatory compounds, mangicols A and C, will be pursued. If the goals of this proposal are achieved, new chemical methods for preparing biologically active molecules will be developed. Ultimately, this contribution will facilitate the discovery of new medicinal agents for treating human illnesses.