Harnessing Strained Intermediates to Access Complex Molecules

利用应变中间体访问复杂分子

基本信息

  • 批准号:
    9523411
  • 负责人:
  • 金额:
    $ 26.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-01 至 2019-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract The central objectives of this application are: (a) to develop new, reliable, and efficient, methodologies that enable the construction of stereochemically rich scaffolds and (b) to achieve the concise chemical syntheses of naturally occurring small molecules that possess intricate chemical structures. The synthesis of complex small molecules continues to be a vital area of research. In fact, most medicinal agents on the market are prepared by organic synthesis, including the large majority of all new drugs that have become available over the past three decades. Additionally, it should be emphasized that natural products serve as valuable leads for the ultimate discovery of new medicines, in addition to inspiration for the development of new synthetic strategies and methods. However, one of the key challenges we now face is uncovering reliable means to construct ever more complex architectures, but with increased efficiency and predictability. This proposal is focused on the development of methodology that will allow chemists to harness transiently generated strained intermediates, such as arynes, heterocyclic alkynes, and heterocyclic allenes, in order to efficiently build complex molecular scaffolds. More specifically, we propose an enamine arylation/alkenylation reaction to establish quaternary stereocenters, in addition to three component couplings, which should allow for the formation of up to two new bonds and two sp3 centers. Next, the use of uncommon and highly reactive heterocyclic allenes to assemble complex architectures through the introduction of up to two new bonds and three sp3 centers is described. Preliminary results demonstrate the feasibility of the proposed methodologies. In the final section, we propose a concise and ambitious total synthesis of acantholactone, a member of the manzamine family of alkaloids that has yet to be synthesized. The results of our studies should lead to powerful new strategies and tools for accessing various molecules of importance, including natural products and medicines.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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NEIL K GARG其他文献

NEIL K GARG的其他文献

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{{ truncateString('NEIL K GARG', 18)}}的其他基金

Exploiting Unconventional Building Blocks in Chemical Synthesis
在化学合成中利用非常规构件
  • 批准号:
    10330994
  • 财政年份:
    2021
  • 资助金额:
    $ 26.93万
  • 项目类别:
NMR Console and Prodigy CryoProbe
NMR 控制台和 Prodigy CryoProbe
  • 批准号:
    10177110
  • 财政年份:
    2021
  • 资助金额:
    $ 26.93万
  • 项目类别:
Exploiting Unconventional Building Blocks in Chemical Synthesis
在化学合成中利用非常规构件
  • 批准号:
    10559768
  • 财政年份:
    2021
  • 资助金额:
    $ 26.93万
  • 项目类别:
Exploiting Unconventional Building Blocks in Chemical Synthesis
在化学合成中利用非常规构件
  • 批准号:
    10727713
  • 财政年份:
    2021
  • 资助金额:
    $ 26.93万
  • 项目类别:
Exploiting Unconventional Building Blocks in Chemical Synthesis
在化学合成中利用非常规构件
  • 批准号:
    10399170
  • 财政年份:
    2021
  • 资助金额:
    $ 26.93万
  • 项目类别:
Exploiting Unconventional Building Blocks in Chemical Synthesis
在化学合成中利用非常规构件
  • 批准号:
    10560628
  • 财政年份:
    2021
  • 资助金额:
    $ 26.93万
  • 项目类别:
Biosynthesis and Enzymology of Antifungal Natural Products
抗真菌天然产物的生物合成和酶学
  • 批准号:
    10513326
  • 财政年份:
    2018
  • 资助金额:
    $ 26.93万
  • 项目类别:
Biosynthesis and Enzymology of Antifungal Natural Products
抗真菌天然产物的生物合成和酶学
  • 批准号:
    10291416
  • 财政年份:
    2018
  • 资助金额:
    $ 26.93万
  • 项目类别:
Biosynthesis and Enzymology of Antifungal Natural Products
抗真菌天然产物的生物合成和酶学
  • 批准号:
    10066257
  • 财政年份:
    2018
  • 资助金额:
    $ 26.93万
  • 项目类别:
New Directions in Cross-Couplings Catalyzed by Non-Precious Metals
非贵金属催化交叉偶联的新方向
  • 批准号:
    9892311
  • 财政年份:
    2016
  • 资助金额:
    $ 26.93万
  • 项目类别:

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Iboga alkaloids骨架导向的不对称串联反应构建吖庚环并[4,5-b]吲哚及其在全合成中的应用
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