CAREER DEVELOPMENT

癌症发展和进展（CDP）研究计划，目前三个， 德克萨斯大学健康中心癌症治疗与研究中心（CTRC）的互动项目 科学中心在圣安东尼奥（UTHSCSA），已经从几个基本要素的合并演变而来， 自上次竞争性更新以来，癌症中心计划。发展政策的主要专题领域是：（1） 基因组完整性，（2）衰老与癌症，（3）慢性炎症与癌症，（4）女性癌症。 重组反映了以前计划领域的一些重大变化，包括离开 几个关键成员和新的癌症重点领域带来的新招募的癌症中心 研究科学家。新的程序化结构提供了一个整合的平台， 有助于合作和综合癌症研究。上述所有主题都有可能 开发或重新开发成强大的，独立的程序在未来，并预计这样做。 CDP计划的总体科学目标是：（1）将基础研究与基因组学相结合， 完整性、年龄相关的癌症易感性、肿瘤微环境、激素作用和治疗 女性癌症的耐药性，以更深入地了解癌症的发展和进展;（2） 促进CDP与人口研究项目之间的跨学科合作， 实验和发育治疗学;（3）转化遗传不稳定性，肿瘤 免疫力、肥胖/营养和激素抵抗等因素，以更好地预防和治疗癌症。 目前，CDP研究计划有23个重点关注癌症和资助的成员，另有25个 受资助的成员进行癌症相关研究，有助于了解癌症 发展和进步。CDP计划中的癌症研究共获得750万美元， 同行评审资金（直接），其中240万美元来自NCI（直接）。在本供资期内， CDP项目的研究人员在癌症的许多领域取得了一些重大成就 生物学这些发现包括双链DNA断裂修复中的新因子，新的分子连接， 遗传不稳定性和衰老之间的关系，对宿主-肿瘤相互作用和分子相互作用的重要见解 激素合成和乳腺癌发展中的作用。随着新的癌症研究重点， 重新配置的互动程序结构和强有力的领导，CDP计划处于有利地位 协同和进一步整合我们癌症中心正在进行的多学科癌症研究。

The Cancer Development and Progression (CDP) research program, one of the three current and interactive programs of the Cancer Therapy & Research Center (CTRC) at the University of Texas Health Science Center at San Antonio (UTHSCSA), has evolved from the merging of essential elements of several cancer center programs since the last competitive renewal. The major thematic areas under CDP are: (1) Genomic Integrity, (2) Aging and Cancer, (3) Chronic Inflammation and Cancer, and (4) Women's Cancer. The reorganization reflects some significant changes in the previous program areas, including the departure of several key members and new cancer focuse areas brought to the Center by newly recruited cancer research scientists. The new programmatic structure provides a consolidated platform that is more conducive to collaborative and integrative cancer research. All of the above themes have the potential to develop or re-develop into strong, stand-alone programs in the future, and are expected to do so. The overarching scientific goals of the CDP Program are: (1) to integrate basic research in genomic integrity, age-related cancer susceptibility, tumor microenvironment, and hormone actions and therapeutic resistance in women's cancer to gain a deeper understanding of cancer development and progression; (2) to foster cross-disciplinary collaboration between CDP and the research programs in population studies and experimental and developmental therapeutics; and (3) to translate findings of genetic instability, tumor immunity, obesity/nutrition, and hormone resistance into better cancer prevention and treatment. Currently, the CDP research program has 23 key cancer-focused and funded members and another 25 funded members who conduct cancer-related research that contributes to the understanding of cancer development and progression. Cancer research in the CDP Program receives a total of $7.5 million in peer-reviewed funding (direct), of which $2.4 million is from the NCI (direct). In the current funding period, researchers in the CDP program have made a number of major accomplishments in many areas of cancer biology. These include discoveries of novel factors in double strand DNA break repair, new molecular links between genetic instability and aging, important insight into host-tumor interactions, and molecular interplay of hormone synthesis and actions in breast cancer development. With new cancer research focus, reconfigured interactive programmatic structure, and strong leadership, the CDP Program is well positioned to synergize and integrate further the multi-disciplinary cancer research ongoing in our Cancer Center.