DATABASE ENVIRONMENT FOR NCMIR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的目标是扩展我们目前的信息技术基础设施，用于管理NCMIR的分布式显微成像数据，并满足BIRN和Telescience项目的要求。正如前面几节所讨论的，NCMIR从各种资源(如仪器、计算工具和科学家)获取大量多维、多分辨率和相关的显微成像信息。促进显微图像信息的快速、准确和全面的存储、传输、检索、联合和理解，是我们的首要目标。信息管理系统将服务于多种目的，包括：1)管理NCMIR研究人员和合作者产生的数量不断增加的成像和实验数据；2)为科学界提供更多访问NCMIR产生的独特三维(3D)数据的途径；3)通过提供反馈和指导，促进断层扫描重建过程；4)将NCMIR的细胞级数据与通过BIRN项目获得的全脑和分子成像数据相结合。我们现有的数据库，细胞中心数据库(CCDB)是作为一个网络可访问的数据库而建立的，以向科学界提供2D和3D光学和电子断层扫描数据。CCDB文件管理系统利用已建立的网格基础设施和先进的数据库管理系统来存储和检索显微镜图像文件和显微镜元数据。如具体目标4A.1.3所述，拟议工作将完善CCDB数据模型，以适应BIRN项目下产生的数据类型。CCDB中的数据将使用作为这一具体目标的一部分开发的工具，与共享的本体和空间框架相联系。这将允许CCDB中的数据与参与BIRN项目的其他地点获得的数据相关联，并跨越多个比例尺。此外，CCDB将与Telescience门户网站安全地整合在一起，以更好地促进高通量断层扫描重建，以支持NCMIR的目标和创建核心区域4A.3.1中概述的“可见细胞”

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this project is to extend our current information technology infrastructure for managing distributed microscopy imaging data at NCMIR and serve the requirements of the BIRN and Telescience projects. As discussed in the preceding sections, NCMIR acquires a high volume of multi-dimensional, multi-resolution, and correlated microscopy imaging information from varied resources such as instruments, computational tools, and scientists. Facilitating the storage, transmission, retrieval, federation and comprehension of microscopy imaging information fast, precise and comprehensive, is our primary goal. The information management system will serve multiple purposes, including: 1) managing the ever increasing amount of imaging and experimental data produced by NCMIR researchers and collaborators; 2) providing greater scientific community access to the type of unique three-dimensional (3D) data produced by NCMIR; 3) facilitating the process of tomographic reconstruction by providing feedback and guidance; 4) integrating cell level data at NCMIR with whole brain and molecular imaging data being acquired through the BIRN project. Our existing database, the Cell Centered Database (CCDB) was established as a web-accessible database to provide both 2D and 3D light and electron tomography data to the scientific community. The CCDB file management system takes advantage of established grid infrastructure and an advanced database management system for storing and retrieving microscopy image files and microscopy metadata. The proposed work will refine the CCDB data model to accommodate the types of data that are being produced under the BIRN project, as described in Specific Aim 4A.1.3. Data in the CCDB will be linked to shared ontologies and spatial frameworks using tools developed as part of this specific aim. This will allow data in the CCDB to be linked to data acquired at other sites participating in the BIRN project and across multiple scales. In addition, the CCDB will be securely integrated with the Telescience Portal to better facilitate high throughput tomographic reconstruction in support of NCMIR's goals and the creation of "Visible Cells" outlined in Core Area 4A.3.1