NW Research Center for Excellence in Biodefense and Emerging Infectious Diseases

X地区西北地区生物防御和新发传染病卓越中心(NWRCE)是全国性生物医学研究计划网络的重要组成部分，旨在应对人口面临的传染病威胁。NWRCE目前是一个高度互动和专题的项目，重点是革兰氏阴性细菌病原体，自成立以来一直存在相同的总体一致的重点。有三个研究主题：(1)革兰氏阴性细菌发病机制，(2)对革兰氏阴性细菌病原体的先天免疫反应，(3)将(1)和(2)转化为预防或治疗革兰氏阴性细菌疾病的早期治疗开发。NWRCE的中心是西雅图的华盛顿大学(UW)；在这次续签申请中，多个地点被提议在西雅图，两个在俄勒冈，一个在爱达荷州，一个在马里兰州。其他合作站点包括蒙大拿州的NIAID落基山实验室、不列颠哥伦比亚省维多利亚大学以及泰国、瑞典和墨西哥的合作者。项目、核心、国内和国际站点以及合作者都是高度互动的。组成这项提案的个人在上一个资助期和西北农村经济委员会成立之前已经共同工作了很多年。大多数新加入的调查人员都与该中心的成员有着长期的合作关系。NWRCE的互动性和重点是该计划的一大优势，使NWRCE能够迅速和灵活地响应国家优先事项，以实现与革兰氏阴性细菌感染有关的重要目标。

The Region X Northwest Regional Center of Excellence (NWRCE) for Biodefense and Emerging Infectious Diseases is an essential component in a nationwide network of biomedical research programs to combat infectious disease threats to the population. The NWRCE is currently a highly interactive and thematic program focused on Gram-negative bacterial pathogens, and the same general consistent focus has existed since its inception. There are three research themes: (1) mechanisms of Gram-negative bacterial pathogenesis, (2) innate immune responses to Gram-negative bacterial pathogens, and (3) translation of (1) and (2) into early stage therapeutic development to prevent or treat Gram-negative bacterial diseases. The NWRCE is centered at the University of Washington (UW) in Seattle; in this renewal application, multiple sites are proposed in Seattle, two in Oregon, one in Idaho, and one in Maryland. Additional sites for collaboration include the NIAID Rocky Mountain Laboratory in Montana, the University of Victoria, British Columbia, and collaborators at sites in Thailand, Sweden, and Mexico. The projects, cores, domestic and international sites, as well as collaborators, are highly interactive. The individuals that make up this proposal have worked together for many years during the last funding period and before the NWRCE was created. The majority of investigators newly added to this to this application for renewed funding of the NWRCE have had long collaborative relationships with members of the center. The interactive nature and focus of the NWRCE is a major strength of the program and allows the NWRCE to rapidly and nimbly respond to national priorities to achieve important objectives with respect to Gram-negative bacterial infections.