RBL-Innate Immunity Core

2002年，蓝丝带小组确定了生物防御的研究优先事项，包括确定优先次序 病原体的研究和广谱疗法的开发，以对抗感染。这包括两个 中心主题：1)发展需要高度控制的生物体的研究能力 实验室和2)研究重点集中在联邦指定的十个地区。在第VII区 华盛顿大学领导中西部地区生物防御和新兴卓越中心 传染病研究(MRCE)。第七区的实验室扩建发生在#年的大学 密苏里州和NIAID区域生物遏制实验室(RBL)。在本提案中，我们描述了 通过建立一个机构，协调研究目标和活动 密苏里大学的先天免疫核心。MRCE的研究项目有一个共同的主题 为了了解对优先病原体的免疫反应机制，参与的研究人员来自 五家机构合作推进这一前沿领域。MU RBL提供最先进的安全壳设计 以及传染病研究的集中资源和教育。通过 先天免疫核心(IIC)我们将创造实验机会，需要获得活细胞分选和 感染样本的其他免疫学技术。此外，IIC和RBL的结构允许 灵活性和适应传染病研究不断变化的前沿。因此，IIC提供了一个 在第七区域的独特能力，为新的科学成就创造机会，从而进一步 MRCE的研究任务。

In 2002, the Blue Ribbon Panel established the research priorities for biodefense, including the prioritization of pathogens and the development of broad spectrum therapeutics to combat infections. This included two central themes: 1) the development of research capacity for organisms requiring high containment laboratories and 2) the centralization of research focus in the ten federally designated regions. In Region VII Washington University directs the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research (MRCE). Laboratory expansion in region VII occurred at the University of Missouri and the NIAID Regional Biocontainment Laboratory (RBL). In this proposal we describe the alignment of research goals and activities between the MRCE and RBL through the establishment of an Innate Immunity Core at the University of Missouri. Research Projects in the MRCE have a common theme to understand mechanisms of immune responses to priority pathogens, and participating researchers from five institutions collaborate to further this frontier. The MU RBL provides state of the art containment design and engineering as well as centralized resources and education for infectious disease research. Through the Innate Immunity Core (IIC) we will create experimental opportunities requiring access to live cell sorting and other immunological techniques on infected samples. Moreover, the IIC and the RBL are strucutred to permit flexibility and adaptation to the changing frontier of infectious disease research. Thus, the IIC provides a unique capability in region VII that creates opportunities for novel scientific achievements that further the research mission of the MRCE.