CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM

对可能影响人类健康的化学品/材料进行毒理学评价是公共卫生研究的一个重要方面。该合同的目的是支持国家毒理学计划（NTP）努力识别和评估可能通过环境暴露影响人类健康的化学制剂。该合同提供了综合化学特性、纯度测定、给药剂量水平确认和内部剂量测定的信息。这些信息对于得出合理和科学的结论至关重要，并支持国家毒理学规划和其他联邦机构的风险评估工作。根据本合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解与接触这些化学品有关的风险因素。国家毒理学规划研究了各种各样的化学品/测试品，例如：溶剂、增塑剂、阻燃剂、膳食/草药补充剂和防晒霜。化学支持合同为NTP提供化学采购，剂量配方和分析，散装材料的散装化学综合分析，以及生物样品方法评估以及确定内部剂量和其他毒性动力学参数的研究。

Toxicological evaluation of chemicals/materials that may affect human health is an important aspect of public health research. The purpose of this contract is to support the National Toxicology Program (NTP) in its efforts to identify and assess chemical agents potentially affecting human health through environmental exposure. This contract provides information on comprehensive chemical characterization, purity determination, confirmation of administered dose levels, and internal dose determinations. This information is critical for sound and scientific conclusions and supports the risk assessment efforts of NTP and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors associated with the exposure with these chemicals. A wide variety of chemicals/test articles are studied by NTP, for example: solvents, plasticizer, flame retardants, dietary/herbal supplements, and sunscreen. The chemistry support contract provides NTP with chemical procurement, dose formulations and analysis, bulk chemical comprehensive analysis of bulk material, along with biological sample method evaluation as well as studies to determine internal dose and other toxicokinetic parameters.