Multicenter AIDS Cohort Study

此申请是对匹兹堡部分进行竞争性续签的提案的B部分 多中心艾滋病队列研究(MACS)合作协议(1UO1-AI-35041)， CAMACS正在提交的综合提案。互委会成立于1983年，是一个纵向的 男男性行为者(MSM)艾滋病自然史研究。此请求是为了获得额外的 为匹兹堡男男性接触者队列的临床随访和实验室检测提供五年支持 Mac电脑。匹兹堡互委会的总体目标是实现A部分主要互委会的具体目标 应用，并在匹兹堡当地进行专门研究，以加强我们的流行病学和发病机制 对治疗干预的认识以及免疫治疗和预防的发展 疫苗。我们的具体目标是确定艾滋病病毒感染的长期自然和治疗史 MSM，描述了对艾滋病毒治疗的反应，包括心理和行为预测因素， 检查HIV和长期HIV治疗暴露对脂肪营养不良、糖尿病、心血管疾病的影响 疾病、肝脏疾病、恶性肿瘤、神经认知功能、物质使用、肾脏疾病和其他 结果，评估老龄化对艾滋病毒和艾滋病毒治疗的临床过程的影响，检查相互作用 在宿主遗传学和HIV之间，定义HIV的发病机制，表征HIV相关的癌症，包括 确定风险因素，确定影响艾滋病毒传播和疾病的社会行为因素 进展，表征伴随感染及其对艾滋病毒疾病进展的影响，检查 药物滥用对抗逆转录病毒治疗效果的影响，保持纵向收集 流行病学数据和生物标本库，作为促进自然历史和 发病机制研究，在匹兹堡Mac中进行MSM的临床和实验室测试，包括T细胞 亚群，抗HIV抗体，HIV病毒载量，乙肝病毒和丙型肝炎病毒检测，血脂/胰岛素/血糖 血药浓度、肝功能测试、肾功能和心血管检查。这项研究与 美国国立卫生研究院治疗和预防艾滋病毒感染和艾滋病的使命。 相关性(请参阅说明)： 作为Mac研究联盟的一部分，匹兹堡Macs计划继续其25年的科学研究 对艾滋病毒/艾滋病自然历史的调查。这项研究为了解艾滋病毒的机制提供了洞察力 感染、艾滋病毒治疗的影响以及艾滋病毒治疗性和预防性疫苗的发展 感染。它与美国国立卫生研究院的艾滋病毒/艾滋病公共卫生项目高度相关。

This application is Part B of a proposal for a competing renewal to the Pittsburgh component of the Multicenter AIDS Cohort Study (MACS) Cooperative Agreement (1UO1-AI-35041), the companion to the Part A composite proposal that is being submitted by CAMACS. The MACS began in 1983 as a longitudinal study of the natural history of AIDS in men who have sex with men (MSM). This request is for an additional five years of support for clinical follow-up and laboratory testing of the cohort of MSM in the Pittsburgh MACS. The broad objectives of the Pittsburgh MACS is to fulfill the specific aims of the Part A master MACS application, and do special studies locally in Pittsburgh to enhance our epidemiologic and pathogenesis knowledge in relation to treatment intervention, and development of immunotherapeutic and prophylactic vaccines. Our specific aims are to determine the long-term natural and treated history of HIV infection in MSM, characterize the responses to HIV therapy, including psychological and behavioral predictors, examine the effects of HIV and prolonged HIV therapy exposure on lipodystrophy, diabetes, cardiovascular disease, liver disease, malignancies, neurocognitive function, substance use, kidney disease, and other outcomes, assess the effects of aging on the clinical course of HIV and HIV therapy, examine the interaction between host genetics and HIV, define HIV pathogenesis, characterize HIV-associated cancers including identification of risk factors, determine socio-behavioral factors that affect HIV transmission and disease progression, characterize concomitant infections and their effects on HIV disease progression, examine the effects of substance abuse on antiretroviral treatment effectiveness, maintain longitudinally collected epidemiological data and biological specimen repository as a platform to facilitate natural history and pathogenesis studies, perform clinical and lab testing of MSM in the Pittsburgh MACS, including T cell subsets, anti-HIV Ab, HIV viral load, hepatitis B virus and hepatitis C virus testing, serum lipid/insulin/glucose levels, liver function tests, renal function and cardiovascular studies. This research has direct relevance to the mission of the NIH to cure and prevent HIV infection and AIDS. RELEVANCE (See instructions): As part of the MACS research consortium, the Pittsburgh MACS proposes to continue its 25 year scientific investigation into the natural history of HIV/AIDS. This research provides insight into the mechanisms of HIV infection, the effects of HIV therapy, and development of therapeutic and preventative vaccines for HIV infection. It is highly relevant to HIV/AIDS public health programs of the NIH.