Graduate Training in Neuroscience

参见说明）： 本申请要求继续支持系统和综合生物学的博士前培训， 特别强调神经科学研究生培训。拟议的培训方案包括 神经科学从研究大脑调节社会活动的机制等复杂系统开始， 与细胞回路的相互作用，这些细胞回路是大脑处理视觉信息的基础， 突触传递的生物学学员获得密集的研究经验，包括正式课程 和个人指导的全方位当代神经科学，包括访问的状态， 用于交互式人类功能性脑成像、细胞的高分辨率光学成像以及 分子复合物，大脑发育的遗传分析，离子通道的电生理学， 神经遗传学、神经生理学和行为的计算分析。学员学习这些方法 正常的大脑功能和大脑紊乱。该计划的目标是为学生的研究做好准备 神经科学的职业生涯，重点是多维方法。为了实现这一目标， 聚集了一个能够指导行为，发展，生物化学， 电生理学、生物物理学、分子生物学、光子学、心理物理学、大规模神经网络 分析，计算神经科学和大脑疾病。我们实施了新的核心课程， 包括分子遗传学和细胞生物学，神经系统发育，感觉运动整合 以及更高级的大脑功能和疾病的神经生物学。我们的计划提供了一个独特的机会， 学生在整个系统发育谱的大脑功能的研究培训，包括在人类中， 健康和疾病。我们已经准备了一系列的考试来测试我们在这方面的努力，我们有 机制到位，以促进学生和教师之间的协作互动，在许多 跨基础和临床科学的部门。我们认为，神经科学的博士前培训 满足了现代生物医学和行为研究的重要国家需求，培训了一批 学生对当代分子，细胞， 系统和行为神经科学。博士生还需要清楚地认识到 神经科学研究中与疾病相关的机会，我们为此增加了疾病的神经生物学 课程跟踪沿着有机会让学生与病人互动，了解动物模型， 人类疾病，并开展合作和共同指导的培训，从基础到转化 research. 相关性（参见说明）： 这一建议继续在神经科学博士前培训计划解决一个主要的国家 卫生需要培养生物医学科学家，对功能、发展进行前沿研究 和脑部疾病。学员学习当代分子、遗传、生理、行为和 计算研究方法在人类和动物健康和疾病中的脑功能。

See Instructions): This application requests continuing support for Predoctoral Training in Systems and Integrative Biology with specific emphasis on Graduate Training in Neuroscience. The training program proposed encompasses Neuroscience from the study of such complex systems as the brain's mechanisms for regulating social interactions to the cellular circuitry that underlie the brain's processing of visual information to the molecular biology of synaptic transmission. Trainees receive intensive research experiences including formal classes and individual mentoring over the full range of contemporary Neuroscience including access to state of the art facilities for interactive human functional brain imaging, high resolution optical imaging of cells and molecular complexes, genetic analysis of brain development, electrophysiology of ion channels and computational analysis of neurogenetics, neurophysiology and behavior. Trainees leam these approaches for normal brain function and for brain disorders. The program's goal is to prepare students for research careers in Neuroscience with an emphasis on multi-dimensional approaches. With this goal in mind we have assembled a faculty able to direct research projects in behavior, development, biochemistry, electrophysiology, biophysics, molecular biology, photonics, psychophysics, large scale neuronal network analysis, computational neuroscience and brain disease. We have implemented a new core curriculum that encompasses molecular genetics and cell biology, nervous system development, sensorimotor integration and higher brain function and the neurobiology of disease. Our program offers a unique opportunity for students to train in the study of brain function across the phylogenetic spectrum, including in humans in health and disease. We have prepared a series of exams to test our progress in this endeavor and we have mechanisms in place to promote collaborative interactions between the students and the faculty in many departments spanning basic and clinical science. We believe that Predoctoral Training in Neuroscience meets an important national need in modern biomedical and behavioral research, the training of a cadre of students with an integrated understanding across the full spectrum of contemporary molecular, cellular, systems and behavioral neuroscience. Ph.D.students also need to gain a clear appreciation of the many disease-related opportunities in Neuroscience research for which we have added a neurobiology of disease course track along with opportunities for students to interact with patients, learn about animal models of human disease and carry out collaborative and jointly mentored training that spans basic to translational research. RELEVANCE (See instructions): This proposed continuation of Predoctoral Training Program in Neuroscience address a major national health need to train biomedical scientists to carry out cutting edge research on the function, development and diseases of the brain. Trainees learn contemporary molecular, genetic, physiological, behavioral and computational research approaches to brain function in human and animal health and disease.