Perceived Fairness and Biological Stress Reactivity

描述（由申请人提供）：关于公平的信念是心血管健康的临床显著预测因素。公平信念通过其影响生物应激过程的能力对心血管健康至关重要。然而，具体种类的公平信念在多大程度上影响重要的生物压力途径在很大程度上是未知的。最终，这些限制阻碍了研究人员更好地了解公平性如何与心血管疾病有关，以及评估以公平为导向的心血管干预措施的能力。这项研究的长期目标是阐明公平在心血管健康中所起的作用，并确定公平是否是一个共同的因果过程，将种族主义，低SES和工作压力等其他风险因素与心血管疾病的后续生物介质联系起来。本申请的目的是实验阐明公平信念和多个生物应激途径的具体测量之间的关系。这个应用程序的中心假设是，程序和分配的公平性将独立和相互依赖地预测更适应的生物应激反应。此外，我们预计，这些关系将反映在特质倾向和情境判断的公平性，也在多个生物和疾病相关的压力途径。具体目标是：（1）衡量分配的独特和互动贡献（有利结果）和程序（2）测量性格（特质）公平性和情境（状态）公平性对生物应激反应的独特和交互作用; 3）测量公平信念和重要的生物应激途径之间的关系，包括血液动力学反应性、HPA轴唤醒和促炎过程的标志物。拟议的研究将管理一个成熟的、基于实验室的压力诱导范式的修改版本。在此过程中，本研究将通过实验评估特定类型的公平信念与多种生物压力途径之间的关联。该项目对公共卫生的影响是重大的。也就是说，拟议的研究将为确定疾病相关模型以及针对和评估心理社会干预措施迈出重要一步。 公共卫生相关性：对公平的信念可以预测压力反应和心血管疾病的发病率。本研究将使用实验方法来评估多种公平信念对生物应激过程的独立和相互依赖的影响。拟议的研究将通过阐明公平信念的独特来源在重要压力途径中的作用，以及通过提出公平与心血管健康之间的因果关系，对公共卫生产生重要影响。

DESCRIPTION (provided by applicant): Beliefs about fairness are a clinically significant predictor of cardiovascular health. Fairness beliefs are fundamentally important to cardiovascular health through their capacity to impact biological stress processes. However, the extent to which specific kinds of fairness beliefs influence important biological stress pathways is largely unknown. Ultimately, these limitations have impeded the capacity of researchers to better understand how fairness is implicated in cardiovascular illness, and also to evaluate fairness-oriented cardiovascular interventions. The long-term goal of this research is to elucidate the role played by fairness in cardiovascular health, and to determine whether fairness is a common causal process linking such other risk factors as racism, low SES, and work stress to subsequent biological mediators of cardiovascular illness. The objective of this application is to experimentally elucidate relationships between specific measurements of fairness beliefs and multiple biological stress pathways. The central hypothesis of this application is that procedural and distributive fairness will independently and interdependently predict more adaptive biological stress reactivity. In addition, we expect that these relationships will be reflected in both trait dispositions and situational judgments of fairness, and also in multiple biological and disease relevant stress pathways. The specific aims are to 1) measure the unique and interactive contributions of distributive (favorable outcomes) and procedural (treatment by others) fairness on biological stress reactivity; 2) measure the unique and interactive contributions of dispositional (trait) and situationally induced (state) fairness on biological stress reactivity; 3) measure relationships between fairness beliefs and important biological stress pathways, including markers of hemodynamic reactivity, HPA axis arousal, and pro-inflammatory processes. The proposed research will administer a modified version of a well established and laboratory-based stress induction paradigm. In doing so, this research will experimentally evaluate associations between specific kinds of fairness beliefs and multiple biological stress pathways. The public health implication of the project is significant. Namely, the proposed research will provide an important step towards defining disease relevant models, and for targeting and evaluating psychosocial interventions. PUBLIC HEALTH RELEVANCE: Beliefs about fairness predict both stress reactivity and incidence of cardiovascular illness. The proposed research will use experimental methodologies to assess independent and interdependent effects of multiple kinds of fairness beliefs on biological stress processes. The proposed research will carry important public health implications by elucidating the role of unique sources of fairness beliefs in important stress pathways, and by suggesting causal links between fairness and cardiovascular health.