Center for Regenerative Medicine (CRM) Support for New Faculty Member

描述(由申请人提供)：本申请旨在为哈佛医学院马萨诸塞州综合医院(MGH)再生医学中心(CRM)的一名新助理教授寻求支持。这个人将被安置在MGH主校区最近完工的CRM实验室和办公空间，作为Simches大楼内10个实际相连的单元的一部分，该大楼有5个跨学科中心。CRM空间是开放的实验室形式，以鼓励互动，包括用于临床级细胞准备的GMP级设施、用于构建生物工程基质的聚合物处理套件和容纳一批生物信息学专家的计算生物学套件。CRM是一个多学科组织，成立于2003年，由来自内科、外科、神经外科、细胞生物学、遗传学、干细胞和再生生物学系的人员组成。经过对70多名候选人的审查，选出了一位在肺发育和再生生物学方面有出色研究记录的内科科学家，以及在肺部疾病方面的临床专业知识。这位候选人，Jayaraj Rajagopal博士，专注于肺干细胞和再生在人类肺部疾病中的应用。 目标：1.)招募一名内科科学家，专注于基于干细胞的治疗人类疾病的方法 2.)建立一个拥有最先进设备的实验室，以加强我们对肺部发育生物学的了解和潜在的肺部疾病应用。培养一位未来肺部疾病再生医学方面的思想领袖。 与血液和心脏干细胞生物学的最新进展形成对比的是，肺方面的工作仍然不发达。我们希望为马萨诸塞州总医院再生医学中心招聘一名新的教员候选人。我们相信，我们的候选人对肺干细胞的治疗用途和发育生物学的兴趣将为肺部的再生医学奠定基础。

DESCRIPTION (provided by applicant): This application is seeking support for a new Assistant Professor in the Center for Regenerative Medicine (CRM), at the Massachusetts General Hospital (MGH), Harvard Medical School. This individual will be located in recently completed laboratory and office space for CRM, on the MGH main campus, as part of a 10 faculty physically adjoined unit within the Simches Building housing five interdisciplinary centers. The CRM space is open lab format to encourage interaction and includes GMP level facilities for clinical grade cell preparations, a polymer handling suite for bioengineered matrix construction and a computational biology suite housing a cadre of bioinformatics experts. The CRM is a multidisciplinary organization established in 2003 incorporating individuals from the Departments of Medicine, Surgery, Neurosurgery, Cell Biology, Genetics and Stem Cell and Regenerative Biology. After review of over 70 candidates, a physician-scientist with a record of excellent research in lung developmental and regenerative biology as well as clinical expertise in lung disease was selected. This candidate, Dr. Jayaraj Rajagopal, is focused on the application of lung stem cells and regeneration to human lung disease. Aims: 1.) To recruit a physician-scientist focusing on stem cell based approaches to human disease 2.) To establish a laboratory with state-of-the-art facilities to enhance our understanding and potential application of lung developmental biology to lung disease.3.) To foster the success of a future thought leader in regenerative medicine for lung disease. In contrast to recent progress in blood and cardiac stem cell biology, work in the lung remains underdeveloped. We wish to recruit a new faculty candidate to the Center for Regenerative Medicine at the Massachusetts General Hospital. We believe our candidate's interest in the therapeutic uses of lung stem cells and developmental biology will lay a foundation for regenerative medicine in the lung.