Yale Cellular Neuroscience, Neurodegeneration and Repair (CNNR) Program

描述(申请人提供)：耶鲁大学细胞神经科学、神经变性和修复项目(CNNR)是由PI和Co-PI于四年前共同创立的，目标是将神经元细胞生物学的基础研究与促进神经退行性疾病和神经修复的病理生理学理解联系起来。我们假设，将疾病导向科学的研究人员与神经系统细胞生物学专家聚集在一起，将产生强大的协同效应。到目前为止，我们已经在连续的实验室空间招聘了5名新教师，将他们与耶鲁大学的其他神经科学家联系在一起，并建立了先进的神经元成像和功能基因组学核心设施。在此，我们建议在耶鲁大学招收两名助理教授，以满足我们项目中尚未得到满足的主要需求。现有教员已经启动的积极的研究计划将与两名新入职人员的研究计划交织在一起，并将促进他们的成功和CNNR的整体成功。预计一名新兵将通过提供单细胞一级的电生理专门知识和光学技术来填补关键作用。使用这些方法的新兵将拥有从现有CNNR教员中挑选分子生物学合作者的肥沃土壤。这样的招募也将为正在进行的健康和疾病中神经功能的探索提供一个新的维度。第二名新兵预计将领导一个以阿尔茨海默病细胞生物学为中心的项目。虽然这是最常见的神经系统疾病，但耶鲁大学没有专门研究这种疾病的实验室。通过这次招募，耶鲁大学神经细胞生物学中心将允许耶鲁大学丰富的神经细胞生物学应用于阿尔茨海默病。重要的是，CNNR的环境将为新的助理教授提供强大的基础科学专业知识和新的想法，以改善对这种疾病的病理生理学理解，并最终获得治疗。耶鲁大学已承诺提供实验室空间，并将为新招聘的人员提供三分之二的资金，但拟议的支持对于为耶鲁CNNR招聘两名新的助理教授提供必要的资源至关重要。

DESCRIPTION (provided by applicant): The Yale Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR) was co-founded by the PI and Co-PI four years ago with the goal of linking basic research in neuronal cell biology with efforts to advance pathophysiological understanding of neurodegenerative disease and neural repair. We hypothesized that strong synergies will result from bringing together researchers in disease-oriented science with experts in the cell biology of the nervous system. To date we have recruited 5 new faculty into contiguous laboratory space, interconnected them with other neuroscientists at Yale, and established an advanced core facility for imaging and functional genomics of neurons. Here, we propose the recruitment of two additional Assistant Professors into the Yale CNNR in order to fill key unmet needs in our Program. The vigorous research programs already launched by existing faculty will interdigitate with those of the two new Recruits and will foster their success and the overall success of the CNNR. It is anticipated that one Recruit will fill a crucial role by providing electrophysiological expertise at the single cell level coupled with optical techniques. A Recruit using these methods will have a fertile ground for selecting molecular biology collaborators from amongst the existing CNNR faculty. Such a Recruit will also provide a new dimension of ongoing explorations of neuronal function in health and disease. The second Recruit is expected to lead a program centered on the cell biology of Alzheimer's Disease. While this is the most prevalent neurological condition, Yale has no laboratory focused primarily on this disorder. With this Recruit, the Yale CNNR will allow the wealth of nerve cell biology at Yale to be applied to Alzheimer's Disease. Importantly, the CNNR environment will provide the new Assistant Professor with a strong basic science expertise and fresh ideas towards an improved pathophysiological understanding, and eventually a treatment, of this condition. Yale has committed laboratory space and will provide two-thirds of the funds for the new Recruits, but the proposed support is essential to provide the resources necessary for recruitment of two new Assistant Professors into the Yale CNNR.