University of Utah Biomedical Research Core Center (P30) in Metabolism and CVD

描述（由申请人提供）：糖尿病和肥胖是心血管疾病的主要危险因素，其发病率在美国正以惊人的速度增长。迫切需要增加我们对导致这些疾病及其并发症的基本机制的理解。犹他大学代谢兴趣小组（MIG）是一个由17个实验室组成的跨学科小组，重点研究燃料和金属代谢的改变如何导致慢性代谢紊乱，如糖尿病及其心血管并发症。自2002年以来，该小组的研究记录非常出色，在该领域发表了200多篇原创同行评议出版物。MIG的一个主要目标是确定线粒体功能障碍导致糖尿病、肥胖及其心血管并发症的新机制。我们已经建立了核心活动，如线粒体表型核心设施，心血管表型核心设施，全动物代谢表型核心设施和代谢组学核心设施。内分泌代谢与糖尿病学部是代谢兴趣小组的重要成员，目前正在积极招募研究活动和兴趣与代谢兴趣小组的广泛目标一致的初级教员。具体来说，候选人将在线粒体生物能量学分析领域带来额外的专业知识，因为它们与心血管危险因素（如肥胖、血脂异常和肥胖相关的心功能障碍）的调节有关。内科和生物化学系为招募该领域的初级教师提供了强有力的机构支持。目前有容纳这些新兵的办公室和研究空间。该应用程序将针对国家心肺和血液研究所，其目标与代谢兴趣小组的目标最密切一致。

DESCRIPTION (provided by applicant): Diabetes and obesity are major risk factors for cardiovascular disease, whose incidence is increasing in the United States at an alarming rate. There is an urgent need to increase our understanding of fundamental mechanisms that lead to these disorders and their complications. The Metabolism Interest Group (MIG) at the University of Utah is an interdisciplinary group comprising 17 laboratories with a focus on studying how altered fuel and metal metabolism leads to chronic metabolic disorders such as diabetes and its cardiovascular complications. The investigative record of this group is outstanding with over 200 original peer reviewed publications in this area since 2002. A major goal of the MIG is to identify novel mechanisms by which mitochondrial dysfunction contributes to diabetes, obesity and their cardiovascular complications. We have established core activities such as a mitochondrial phenotyping core facility, a cardiovascular phenotyping core facility a whole animal metabolic phenotyping core facility and a metabolomics core facility. The Division of Endocrinology Metabolism and Diabetes is an integral member of the Metabolism Interest Group and is actively recruiting junior faculty whose research activity and interests will be consonant with the broad goals of the Metabolism Interest Group. Specifically, candidates will bring additional expertise in the area of mitochondrial bioenergetics analyses as they relate to the regulation of cardiovascular risk factors such as obesity and dyslipidemia and obesity-associated cardiac dysfunction. There is strong institutional support from the Department of Internal Medicine and Biochemistry for recruiting junior faculty in this area. Office and research space to accommodate these recruits is currently available. The application will be targeted to the National Heart Lung and Blood Institute, whose goals most closely align with those of the Metabolism Interest Group. The prevalence of diabetes and obesity are increasing at an alarming rate, and are major risk factors for cardiovascular disease. There is a pressing need for investigation into the pathogenesis and treatment of CVD in these disorders, and progress is most likely to be made in interdisciplinary research groups such as the Metabolism Interest Group of the University of Utah School of Medicine.