Core Grant For Vision Research

描述(由申请人提供)：这份P30提案申请资金，以支持匹兹堡大学眼科学和视觉科学研究中心(OVSRC)内五个资源模块的运作。OVSRC为匹兹堡地区21名视力科学家的基础和临床视力研究提供了一个大本营。其中，13个是NEI资助的(拥有13个R01赠款、1个T32赠款、1个待激活的K22和3个分包合同)，3个是通过其他NIH研究所资助的，其余的调查人员是通过私人资助机构资助的。核心赠款模块主要支持NEI资助的调查人员，以及正在生成最终将导致NEI支持的试点数据的新调查人员。核心资助参与者的科学学科包括细胞生物学、细胞信号、病毒学、免疫学、发育生物学、分子遗传学、神经生物学、电生理学和眼睛成像技术。核心资助模块旨在支持这些科学学科，包括：1)图像采集和分析，2)基因表达/蛋白质组学，3)杂交瘤/组织培养，4)分子生物学，5)流式细胞术。所有模块都集中在OVSRC内，位于眼耳研究所的9层和10层。在过去的20年里，Core Grant通过提供尖端技术，促进将该技术纳入研究项目，并促进科学家和内科科学家之间的合作，极大地促进了匹兹堡地区的视力研究。

DESCRIPTION (provided by applicant): This P30 proposal requests funding to support the operation of five resource modules within the Ophthalmology and Visual Sciences Research Center (OVSRC) at the University of Pittsburgh. The OVSRC provides a home base for the basic and clinical vision research of 21 vision scientists in the Pittsburgh area. Of these, 13 are NEI funded (holding 13 R01 grants, 1 T32 grant, 1 K22 to be activated and 3 subcontracts), 3 are funded through other NIH institutes, and the remaining investigators are funded through private funding agencies. The core grant modules primarily support the NEI-funded investigators, and new investigators who are generating pilot data that will lead ultimately to NEI support. The scientific disciplines of the core grant participants include cell biology, cell signaling, virology, immunology, developmental biology, molecular genetics, neurobiology, electrophysiology, and ocular imaging technologies. The core grant modules are designed to support these scientific disciplines, and include: 1) image acquisition & analysis, 2) gene expression/proteomics, 3) hybridoma/tissue culture, 4) molecular biology, and 5) flow cytometry. All modules are centrally housed within the OVSRC on the 9th and 10th floors of the Eye and Ear Institute. For the past 20 years the Core Grant greatly enhanced vision research in the Pittsburgh area by providing cutting edge technology, facilitating the incorporation of that technology into research projects, and facilitating collaboration among scientists and physician scientists.