CORE--Neuropathology/Histochemistry

该提案旨在建立埃默里神经科学NINDS核心设施。神经科学研究在埃默里大学发展迅速，近年来有数十名新的研究人员获得了NINDS的资助。该研究基于10多个基础科学和临床部门，追求的关键问题，从神经功能的细胞和分子基础和神经系统疾病的机制，到中风和其他常见疾病的新疗法的临床试验。埃默里神经科学NINDS核心设施将协调37名NINDS资助的研究人员及其51名合格赠款的核心活动，为这些研究人员和其他神经科学家提供各种最先进的技术和方法，以加强合作，多学科研究。该设施将利用慷慨的机构支持人员，设备，空间和新的神经退行性疾病中心，以开发或扩大以下共享核心设施：a）蛋白质组学B）成像c）神经病理学/组织化学d）病毒载体和e）基因组学。作为董事，艾伦·利维博士和雷·丁格尔丁博士将通过以下方式为中心提供出色的行政支持：a）促进、协调和监督核心的访问; B）协助预算编制、报告和维护财政责任; c）提供一个利用尖端技术和多学科方法促进合作研究的环境。由中心主任和各核心领导人组成的指导委员会将至少每6个月举行一次会议，以确保公平访问，监督核心的运作，并确定优先事项和解决问题。神经系统疾病是发病率和死亡率的主要原因。本申请中描述的核心将促进埃默里大学NINDS赞助的广泛研究，旨在提高对疾病的理解，并产生新的诊断方法，疗法和预防。

This proposal seeks to establish the Emory Neuroscience NINDS Core Facilities. Neuroscience research has grown dramatically at Emory, with dozens of new investigators receiving NINDS-funding in recent years. The research, based in more than 10 basic science and clinical departments, pursues key issues ranging from the cellular and molecular basis of neural function and mechanisms of neurological disease, to clinical trials of new therapies in stroke and other common diseases. The Emory Neuroscience NINDS Core Facilities will coordinate core activities for 37 NINDS-funded investigators and their 51 qualifying grants, to provide these investigators and other neuroscientists access to a variety of state-of-the-art technologies and approaches that will enhance collaborative, multidisciplinary research. The facility will leverage generous institutional support for personnel, equipment, space and the new Center for Neurodegenerative Disease, to develop or expand the following shared core facilities: a) Proteomics b) Imaging c) Neuropathology/Histochemistry d) Viral Vector and e) Genomics. As directors, Drs. Allan Levey and Ray Dingledine will provide outstanding administrative support for the Center by a) facilitating, coordinating and monitoring access to the cores; b) assisting with budgeting, reporting, and maintaining fiscal responsibility; and c) providing an environment that fosters collaborative research utilizing cutting edge technologies and multidisciplinary approaches. A steering committee comprised of the Directors of the Center and the leaders of the respective Cores will meet at least once every 6 months to assure fair access, provide oversight of the operations of the cores, and to establish priorities and resolves issues. Neurological disorders are major causes of morbidity and mortality. The cores described in this application will facilitate a broad range of NINDS-sponsored research at Emory that is aimed at improving the understanding of disease, and producing new diagnostic approaches, therapies, and prevention.