11th International Conference on Developmental Nephrology

项目概述：国际发育肾病研讨会成立于1980年，最初是一个小型会议论坛，供研究人员交流意见，并对最近专注于肾脏胚胎发生、出生后功能发育和肾脏代谢的工作进行批判性评估。讲习班取得了不折不扣的成功，并促使组织了后来的三年一次的会议，这些会议已被广泛认为是主要的小型肾脏病会议之一。第11届国际发育肾脏学研讨会题为“遗传编程与肾脏：健康和疾病中的前体细胞、信号和形态发生”，是第11届儿科肾脏学家、发育生物学家、发育生理学家、细胞生物学家和遗传学家的国际聚会，讨论新的科学进展，并参与与发育中的肾脏和尿路的生物学、病理生理学和遗传学有关的思想和概念的动态交流。目前的R13申请寻求资金，以支持高级博士后和研究员以及年轻调查人员的旅行奖励。虽然基金会、企业赞助商和国际儿科肾病协会(IPNA)的资金将用于支付基本的会议费用，但所申请的R13资金将作为我们唯一的资金来源，为高级实习生和初级研究人员提供最多10笔旅行补助金。我们相信，第11届国际发展肾病研讨会的会议形式和优秀的演讲者名单将为合格的初级教师和高级博士后提供独特的教育机会。他们不仅会接触到尖端科学，而且研讨会场地非常有利于小组讨论和互动，这应该会在参与者之间引发新的协作互动。会议将于2010年8月24日至27日在纽约新帕尔茨举行，紧接着第14届IPNA大会将在纽约市举行。 公共卫生相关性：项目叙述在过去的50年里，发育的肾脏生理学已经演变为一个与儿科肾病作为临床学科发展同时的研究领域。到1980年，这一领域的研究人员数量已经达到临界值，促使在纽约组织了第一届发育肾生理学国际研讨会。第一期讲习班的成功促成了随后每隔3年举办一次讲习班，每次讲习班都是结合国际儿科肾病学会(IPNA)三年一次的大会举行的。这些研讨会最初的目的是提供一个全面的计划，突出最近在发育肾病方面的进展。然而，最近细胞和分子生物学的爆炸性发展，以及肾脏疾病的分子遗传学，吸引了来自许多学科的研究人员将他们的注意力集中在发育中的肾脏上。组织了第11届国际发育肾脏学讲习班，题为“遗传规划与肾脏：健康和疾病中的祖细胞、信号和形态发生”，包括来自儿科肾病学、肾脏内科、生理学、细胞生物学、发育生物学、病理学、分子生物学和遗传学等多个学科的研究人员。在这两天半的会议中，三个最先进的演讲将集中讨论从1)祖细胞群体的调节，到2)发育器官的活细胞成像，到3)影响细胞分化的小分子的筛选。将举办六场研讨会，主题包括：1)干细胞、祖细胞和再生；2)后肾区的分子机制和模式；3)肾脏收集系统的形态发生；4)肾单位形成的信号和控制；5)下尿路的模式和形态发生；以及6)分子信号和上皮分化。每一次会议将包括更知名的调查人员和更年轻的调查人员。此外，将鼓励与会者提交摘要，以便在两个海报讨论环节中展示。我们相信，第11届国际发展肾病研讨会的会议形式和优秀的演讲者名单将为合格的初级教师和高级博士后提供一个特别重要的教育机会。他们不仅会接触到尖端科学，而且研讨会场地非常有利于小组讨论和互动，这应该会在参与者之间引发新的协作互动。此R13应用程序的目标是为最多10名年轻科学家提供部分旅行和住宿支持，以参与这一动态会议。

DESCRIPTION (provided by applicant): PROJECT SUMMARY The International Developmental Nephrology Workshop was initiated in 1980 as a small meeting forum for investigators to exchange ideas and critically evaluate recent work focused on renal embryogenesis, postnatal functional development, and renal metabolism. The Workshop was an unqualified success and spurred the organization of subsequent triennual meetings that have become widely recognized as one of the premier small nephrology meetings. The 11th International Developmental Nephrology Workshop entitled "Genetic Programming and the Kidney: Progenitors, Signaling and Morphogenesis in Health and Disease" represents the 11th international gathering of pediatric nephrologists, developmental biologists, developmental physiologists, cell biologists, and geneticists to discuss new scientific advances and engage in dynamic exchanges of ideas and concepts relating to the biology, pathophysiology, and genetics of the developing kidney and urinary tract. The current R13 application seeks funding to support travel awards for senior post-docs and fellows, as well as young investigators. While funding from foundations, corporate sponsors, and the International Pediatric Nephrology Association (IPNA) will cover the basic meeting expenses, the requested R13 funds will serve as our sole funding source for awarding up to 10 travel grants for senior trainees and junior investigators. We believe that the meeting format and the outstanding slate of speakers assembled for the 11th International Developmental Nephrology Workshop will provide a unique educational opportunity for qualified junior faculty and senior post-docs. Not only will they be exposed to cutting edge science, but the Workshop venue is highly conducive to small group discussions and interactions that should spark new collaborative interactions among the participants. The meeting will be held in New Paltz, New York from August 24-27, 2010, immediately preceding the 14th IPNA Congress to be held in New York City. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Over the past 50 years, developmental renal physiology has evolved as an investigative field concurrent with the development of pediatric nephrology as a clinical discipline. By 1980, the number of investigators in this field had reached a critical mass, prompting the 1st International Workshop on Developmental Renal Physiology to be organized in New York. The success of this initial Workshop led to the organization of subsequent Workshops at 3-year intervals, each in conjunction with the triennial Congress of the International Pediatric Nephrology Association (IPNA). These Workshops initially aimed to provide a comprehensive program that highlighted recent advances in developmental nephrology. However, the recent explosion in cellular and molecular biology, as well as the molecular genetics of renal disease, has enticed investigators from many disciplines to focus their attention on the developing kidney. The 11th International Developmental Nephrology Workshop entitled "Genetic Programming and the Kidney: Progenitors, Signaling and Morphogenesis in Health and Disease" has been organized to embrace investigators from a broad range of disciplines, including pediatric nephrology, renal medicine, physiology, cell biology, developmental biology, pathology, molecular biology and genetics. In this two and a half day meeting, three State-of-the-Art presentations will focus on topics ranging from 1) The regulation of progenitor populations, to 2) live cell imaging in developing organs, to 3) screening for small molecules that affect cell differentiation. Six symposia will be presented with topics that include: 1) Stem Cells, Progenitors, and Regeneration; 2) Molecular mechanisms and patterning of the metanephric field; 3) Morphogenesis of the Renal Collecting System; 4) Signaling and Control of Nephron Formation; 5) Patterning and Morphogenesis of the Lower Urinary Tract; and 6) Molecular Signaling and Epithelial Differentiation. Each session will include more well-established investigators and younger investigators. In addition, participants will be encouraged to submit abstracts for presentation in two poster discussion sessions. We believe that the meeting format and the outstanding slate of speakers assembled for the 11th International Developmental Nephrology Workshop will provide a particularly important educational opportunity for qualified junior faculty and senior post-docs. Not only will they be exposed to cutting edge science, but the Workshop venue is highly conducive to small group discussions and interactions that should spark new collaborative interactions among the participants. The goal of this R13 application is to provide partial travel and lodging support for up to 10 young scientists to participate in this dynamic meeting.