Chemistry of Preventing and Combating Disease

描述（由申请人提供）：本申请要求支持美国化学会（ACS）第240届全国会议和博览会的规划，该会议将于2010年8月22日星期日至8月25日星期三在马萨诸塞州波士顿举行。这次ACS会议的一个独特之处在于整个会议的广泛主题——“预防和对抗疾病的化学”，它使ACS所有部门的规划重点事件保持一致。美国化学学会化学毒理学分部的使命是促进对导致疾病过程的化学机制以及环境剂、药物和内源性化学品的毒性的理解。该部门整合了化学、化学生物学、结构生物学、毒理学、环境健康科学和疾病机制方面的工作。“预防和防治疾病的化学”全球主题与化学毒理学司的核心重点领域密切一致，因此提供了一个专题背景，加强了该司的方案拟订工作，并特别为学生和博士后研究员提供了相关内容。围绕“预防和对抗疾病的化学”这一中心主题，计划举行四场相互关联的会议，其中包括邀请不同群体的知名和崭露头角的科学家发表演讲，介绍他们最近的研究成果。要求提供支助的两届会议与NIEHS的使命特别密切相关。第一场（专题研讨会#1）题为“蛋白质加合物和应激反应途径”，并讨论了亲电试剂和活性氧和氮物种通过选择性修饰蛋白质靶点触发应激和适应性信号通路的分子机制。第二场（专题研讨会#4）题为“炎症标志物和干预”，并讨论了炎症反应物质的化学作用，炎症过程中可能作为生物标志物的特征分子物种的形成，以及炎症作为与环境暴露相关的疾病过程的整合机制的作用。提供的论文会议和青年研究者研讨会为青年研究者提供了展示其主要贡献的机会。其他亮点是主题奖研讨会和科学观点演讲。

DESCRIPTION (provided by applicant): This application requests support for programming of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 240th National Meeting and Exposition in Boston, MA from Sunday, 22-Aug-2010 to Wednesday, 25-Aug-2010. A unique feature of this ACS meeting is the broad theme of the entire meeting--"Chemistry of Preventing and Combating Disease," which aligns highlighted events across the programming of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms that contribute to disease processes and the toxicity of environmental agents, drugs and endogenous chemicals. The division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. The global theme "Chemistry of Preventing and Combating Disease" aligns closely with the core focus areas of the Division of Chemical Toxicology and thus provides a thematic backdrop that reinforces programming in the Division and provides related content particularly for students and postdoctoral fellows. Four interrelated sessions are planned around the central theme "Chemistry of Preventing and Combating Disease" and include invited talks by a diverse group of leading established and up-and-coming scientists presenting their recent research results. The two sessions for which support is requested have especially strong relevance to the mission of the NIEHS. The first (Symposium #1) is entitled "Protein adducts and stress response pathways" and addresses molecular mechanisms by which electrophiles and reactive oxygen and nitrogen species trigger stress and adaptive signaling pathways by selective modification of protein targets. The second (Symposium #4) is entitled "Inflammation markers and interventions" and addresses the chemistry of reactive species involved in inflammation, the formation of characteristic molecular species that may serve as biomarkers for inflammatory processes and the role of inflammation as an integrating mechanism for disease processes associated with environmental exposures. Proffered paper sessions and a Young Investigators Symposium offer opportunities for young investigators to present their primary contributions. Other highlights are a keynote awards symposium and scientific perspectives address. PUBLIC HEALTH RELEVANCE: Effective prevention and treatment of environmentally-related diseases requires an understanding of underlying mechanisms that link environmental exposures to disease mechanisms. This meeting of the Division of Chemical Toxicology of the American Chemical Society will examine the chemical mechanisms by which molecular damage translates to disease. Specifically, the sponsored symposia will examine new work on how inflammation and molecular damage processes create signals that trigger environmentally-induced disease processes.