Fourth Annual Symposium on Nephrogenic Systemic Fibrosis and Gadolinium Based Con

描述（由申请人提供）：耶鲁大学医学院和纽约科学院正在计划一个为期一天半的重要会议，题为“第四届肾源性系统性纤维化和钆基造影剂年会”。“这次会议将于2010年5月14日至15日在纽约的纽约科学院举行。本次会议的首席研究员是Ali K. Abu-Alfa，MD，Festival;医学副教授;内科学系;肾脏科;耶鲁大学医学院;这项研究的共同负责人是肖恩·E·考珀，皮肤病学和病理学副教授，皮肤科，耶鲁大学医学院。本次会议将讨论肾源性系统性纤维化（NSF），这是一种罕见的皮肤病，已知与钆基磁共振成像造影剂（GBCA）高度相关，并且很可能由其引发。这种人为的疾病主要发生在既存肾功能不全的个体中。总的来说，讨论的广度将从负责NSF的细胞和原子扩展到处于危险中的整个人群。讨论将检查NSF的治疗和机制方面，以便从临床和科学的角度更好地了解这种罕见的疾病。此外，将讨论需要使用GBCA进行MR诊断性磁共振成像（MRI）的高危患者的管理。也许更重要的是，这项工作将对一般纤维化的基本理解产生影响，为研究以前被认为是医学不可挑战的疾病机制开辟了新的途径。这次会议将汇集临床医生和科学家，主要是在肾脏病学，放射学，风湿病学，皮肤病学和病理学。与会者将包括既有和年轻的职业科学家和临床医生，为下一代进入这一领域提供一个平台。此外，本次会议预计将增加互补研究小组之间的沟通和随后的合作。 项目叙述 本次会议将讨论肾源性系统性纤维化（NSF），这是一种罕见的皮肤病，已知与钆基磁共振成像造影剂高度相关，并且很可能由钆基磁共振成像造影剂引发。这种人为的疾病主要发生在预先存在肾功能不全的个体中。讨论将研究NSF的治疗和机制方面，从临床和科学的角度来研究这种罕见的疾病。也许更重要的是，这项工作将对纤维化的基本理解产生影响，为理解以前被认为是医学不可挑战的疾病机制开辟了新的途径。

DESCRIPTION (provided by applicant): Yale School of Medicine and The New York Academy of Sciences are planning an important 1.5 day conference entitled, "Fourth Annual Symposium on Nephrogenic Systemic Fibrosis and Gadolinium Based Contrast Agents." This meeting will be held on May 14-15, 2010 at the New York Academy of Sciences, New York. The principal investigator for this conference is Dr. Ali K. Abu-Alfa, MD, FASN; Associate Professor of Medicine; Department of Internal Medicine; Section of Nephrology; Yale School of Medicine; Co PI on this grant is Dr. Shawn E. Cowper, Associate Professor of Dermatology and Pathology; Department of Dermatology; Yale University School of Medicine. This meeting will discuss Nephrogenic Systemic Fibrosis (NSF), a rare skin disorder known to be highly associated with, and very likely triggered by, gadolinium based magnetic resonance imaging contrast agents (GBCA). This man-made disease predominates in individuals with preexisting renal dysfunction. Overall, the breadth of discussions will extend from the cells and atoms responsible for NSF to the entire population at risk. Discussions will examine the therapeutic and mechanistic aspects of NSF as to better understand this rare disease from both a clinical and scientific viewpoint. In addition, the management of patients at-risk in need of MR diagnostic magnetic resonance imaging (MRI) with GBCA will be discussed. Of greater importance, perhaps, is the impact this work will have on the fundamental understanding of fibrosis in general, opening up new avenues of inquiry into disease mechanisms previously thought to be unchallengeable by medicine. This meeting will bring together clinicians and scientists, chiefly in nephrology, radiology, rheumatology, dermatology and pathology. Participants will include both established and young career scientists and clinicians, providing a platform for the next generation to enter this field. Furthermore, this conference is anticipated to increase communication and subsequent collaboration between complimentary research groups. Project Narrative This meeting will discuss Nephrogenic Systemic Fibrosis (NSF), a rare skin disorder known to be highly associated with, and very likely triggered by, gadolinium based magnetic resonance imaging contrast agents. This man-made disease predominates in individuals with pre-existing renal dysfunction. Discussions will examine the therapeutic and mechanistic aspects of NSF to examine this rare disease from both a clinical and scientific viewpoint. Of greater importance, perhaps, is the impact this work will have on the fundamental understanding of fibrosis in general, opening up new avenues of understanding into disease mechanisms previously thought to be unchallengeable by medicine.