Sensory Processing Dysfunction in Neuropsychiatric Illness

描述（由申请人提供）：这是根据计划公告PAR-06-357在综合行为科学中建立转化研究的R24奖的申请。近几十年来，NIH的长期投资已经在情感、动机和认知等领域产生了大量的知识。然而，来自基础行为科学的理论、方法、知识和见解并没有被充分利用来理解精神分裂症等紧迫的公共卫生问题。该项目的总体目标是建立一个合作网络，鼓励将基本行为理论、方法和发现系统地转化为旨在减轻精神疾病行为障碍，特别是精神分裂症负担的研究。核心项目由一名临床研究人员（Javitt）和两名基础行为科学研究人员（Hillyard，Schroeder）之间的合作组成，将神经认知基础科学的最新进展转化为精神分裂症的研究，并将精神分裂症感觉处理功能障碍的最新发现转化为改进的基础和转化模型的发展。感觉功能障碍是转化研究的理想模型，因为组成过程很容易被基础行为科学家研究并转化为动物模型。此外，在该领域正在进行的行为研究允许现有的措施和基础和行为科学家之间的递归交互的细化。精神分裂症患者的感觉处理缺陷“向上概括”，导致更全面的过程，如物体识别、阅读和情感识别的缺陷。本项目期间的研究将侧重于提高进行转化研究的能力，包括发展新的范式、合作和基础设施。

DESCRIPTION (provided by applicant): This is an application for an R24 award under program announcement PAR-06-357 Building Translational Research in Integrative Behavioral Science. Long-term investment by NIH over recent decades has resulted in a large body of knowledge in such areas as emotion, motivation, and cognition. However, the theory, methods, knowledge and insights from the basic behavioral sciences have not been fully utilized in understanding pressing public health issues such as schizophrenia. The overall goal of this project is the development of a network of collaborations that will encourage the systematic translations of basic behavioral theory, methods and findings into research designed to reduce the burden of mental illness behavioral disorders, particularly schizophrenia. The core project consists of a collaboration between one clinical researcher (Javitt) and two basic behavioral science researchers (Hillyard, Schroeder) to translate recent advances in the basic science of neurocognition to the study of schizophrenia, and to translate recent findings of sensory processing dysfunction in schizophrenia to the development of improved basic and translational models. Sensory dysfunction represents an ideal model for translational research, in that component processes are readily amenable to study by basic behavioral scientists and for translation to animal models. Further, ongoing behavioral research in the area permits refinement of existing measures and recursive interaction between basic and behavioral scientists. Deficits in sensory processing in schizophrenia "upward generalize" to cause deficits in more holistic processes such as object recognition, reading, and emotion identification. Studies during the present project period will focus on enhancement of capabilities to conduct translational research, including development of new paradigms, collaborations and infrastructure.