WORKSHOP ON BIOLOGICAL SMALL ANGLE X-RAY SCATTERING AND DIFFRACTION STUDIES IN S

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该中心于2009年4月9日至12日主办了一次关于结构生物学中主要非晶态X射线衍射研究的研讨会。它包括两天的讲座和两天的实践课。讲座涵盖了非晶态物质X射线散射的理论和实验方面、数据解释的计算方法以及一些最新的研究成果。讲习班的主要重点是溶液X射线散射研究，目前这一研究占BL4-2上束流时间分配的50%以上。讲习班还讨论了相关主题，包括最近关于偏序体系的脂类和纤维X射线衍射研究。大多数与会者使用大分子结晶学作为他们的主要结构工具，并对使用非晶体衍射技术，主要是溶液X射线散射，以补充他们的更高分辨率的结构研究感兴趣。研讨会有15名讲师/导师和20名参与者，其中包括来自其他同步加速器设施的类似中心的几名成员。在实验实践环节中，10名参与者每人被分配了大约2小时的BL4-2束流时间来测量他们自己的样本。SMB工作人员主持了这些实验课程，Dmitri Svergan(EMBL-汉堡)和SJ Kim(Sali集团，加州大学旧金山分校)主持了计算实践课程，大多数参与者和许多讲师参加了这些课程。一些讲习班参与者后来提交了快速访问或标准实验提案，以继续他们的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center hosted a workshop on primarily non-crystalline x-ray diffraction studies in structural biology on April 9-12, 2009. It consisted of 2 days of lectures and 2 days of practical sessions. The lectures covered theoretical and experimental aspects of x-ray scattering by non-crystalline matter, computational methods for data interpretation as well as some of most recent research results. The primary focus of the workshop was solution x-ray scattering studies, which currently make up over 50% of beam time allocation on BL4-2. The workshop also covered related topics including recent lipid and fiber x-ray diffraction studies which deal with partially ordered systems. The majority of the participants uses macromolecular crystallography as their primary structural tool, and was interested in using non-crystalline diffraction techniques, primarily solution x-ray scattering, to complement their higher resolution structural studies. There were 15 lecturers/tutors and 20 participants in the workshop, including several from similar Centers from other synchrotron facilities. Approximately 2 hours of beam time on BL4-2 was allocated to each of ten participants in the experimental practical sessions to measure their own samples. The SMB staff hosted these experimental sessions, and Dmitri Svergun (EMBL-Hamburg) and SJ Kim (Sali group, UCSF) led computational practical sessions, which were attended by most of the participants and many lecturers. Some of the workshop participants later submitted rapid access or standard experimental proposals to continue their studies.