D- CHIRO-INOSITOL IS ABSORBED BUT NOT SYNTHESISED IN RODENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 D-甲基肌醇(DCI)和品尼醇(1D-3-O-甲基-甲基肌醇)是两种独特的肌醇，据报道它们具有类似胰岛素的特性。含DCI的化合物在常见的实验动物饲料中含量丰富。通过对6m-HCl水解物的GC-MS分析，Purina实验室啮齿动物饲料5001(饲料5001)含有0.23%的总DCI，其中大部分存在于紫花苜蓿和豆粕成分中。相比之下，只观察到了微量的L-肌醇。DCI部分以水溶性非离子形式存在，其中大部分是Pinitol。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. d-chiro-inositol (DCI) and pinitol (1d-3-O-methyl-chiro-inositol) are distinctive inositols reported to possess insulin-mimetic properties. DCI-containing compounds are abundant in common laboratory animal feed. By GC-MS of 6 m-HCl hydrolysates, Purina Laboratory Rodent Diet 5001 (diet 5001) contained 0.23 % total DCI by weight with most found in the lucerne and soya meal components. In contrast, only traces of l-chiro-inositol were observed. The DCI moiety was present in a water-soluble non-ionic form of which most was shown to be pinitol.