Advanced Instrumental Development Core: Medical College of Wisconsin

这一核心提供了来自公认为世界领先的EPR仪器开发地点的意见，即威斯康星医学院(MCW)的国家生物医学EPR中心。这一核心的作用将是在开发实现CMCR目标所需的技术的特定方面方面提供领导。这些开发将与这些项目和达特茅斯的仪器核心合作进行，以促进为电子顺磁共振剂量学开发尽可能最好的原型仪器。MCW的核心贡献在四个具体目标中进行了描述。具体目标1(50%的工作)是开发用于指甲和牙齿的X波段活体测量的谐振器；这将是最广泛的项目，将专注于利用在最初的合作研究中取得的突破，其中首次成功地使用在非常敏感的X波段频率工作的谐振器进行活体测量。这一发展是核心 在拨款过程中，这个核心将尝试制造类似的谐振器，可以 用于活体牙齿剂量测定，这可以显著提高本已令人印象深刻的敏感性 方法(项目1)。具体目标2(工作的25%)--开发工具以支持 X波段的测量将特别侧重于开发专门设计的微波桥 这将促进两个项目2和3。这些开发将与一个长期合作的 海德博士和斯沃茨博士的合作伙伴，雅盖隆大学的弗朗西兹博士 在克拉科夫，Froncisz博士的支持将通过购买协议来实现。具体目标3(努力的20%)- L波段测量用谐振器和电桥的改进。这个核心同样将与达特茅斯和克拉科夫合作开发改进的L频段电桥，以支持项目1。它还将通过使用MCW高度开发的非常复杂的建模技术来促进项目1中的谐振器的开发，这些技术使不同配置的谐振器e=得到严格的评估，以便施工可以专注于可能成功的设计特定目标4-(5%的努力)支持多频率研究将提供一套特殊的EPR光谱仪，这对所有三个项目都有价值，有助于阐明EPR谱中潜在重叠成分的特征。

This core provides input from what is generally agreed to be the leading EPR instrumental development site in the world, the National Biomedical EPR Center at the Medical College of Wisconsin (MCW). The role of this core will be to provide leadership in the development of specific aspects of the technology needed to accomplish the goals ofthe CMCR. These developments will be carried out in collaboration with the projects and with the instrumental Core at Dartmouth, to facilitate the development of the best possible o prototype instruments for EPR dosimetry. The contributions ofthe core at MCW are described in four specific aims. Specific Aim 1 (50% of effort) is the Development of resonators for measurements at X-Band in vivo for nails and teeth; this will be the most extensive project and will focus on exploiting the breakthrough achieved in initial collaborative studies where for the first time, resonators that operate at the very sensitive X-Band frequency were successfully used to make measurements in vivo. This development is at the heart of project 3. During the course of the grant this core will attempt to make analogous resonators that can be used for in vivo tooth dosimetry, which could dramatically improve the already impressive sensitivity of this approach (Project 1). Specific Aim 2 (25% of effort) - Development of instrumentation to support measurements at X-Band, will especially focus on development of specifically designed microwave bridges that will facilitate both Projects 2 &3. These developments will be carried out in collaboration with a longstanding collaborative partner of both Dr. Hyde and Dr. Swartz, Dr. Froncisz of the Jagiellonian University in Krakow (Dr. Froncisz's support will come via a purchase agreement. Specific Aim 3 (20% of effort) - Improvements in resonators and bridges for measurements at L-Band. This core will similarly work with Dartmouth and Krakow in the development of improved L-Band bridges, in support of Project 1. It also will facilitate resonator development in project 1 by use ofthe very sophisticated modeling techniques that are highly developed at MCW, which enable different configurations of resonators to e=be rigorously evaluated so that construction can be focused on designs that are likely to be successful Specific Aim 4 -(5 % of effort) support of multifrequency studies will available an exceptional set of EPR spectrometers that can be of value to all three projects in helping to elucidate the characteristics of potentially overlapping components of EPR spectra.