The Sixth International Mdm2 Workshop

描述(申请人提供)：P53蛋白已被很好地描述为在人类癌症中发挥肿瘤抑制作用。事实上，大多数人类肿瘤都存在TP53基因的错义突变。MDM2是P53的负调控因子，通过直接结合抑制P53的转录活性，并作为E3泛素连接酶作用于P53的降解。与这些发现一致的是，MDM2被认为在人类肿瘤中也起到了作用，在各种癌症中观察到了它的过度表达或基因放大。每两年举行一次P53讲习班，将P53领域聚集在一起，以报告最新研究，并促进合作和试剂交流。2010年，第15届国际P53研讨会在宾夕法尼亚州费城举行。12年前，组织了一个相辅相成的MDM2讲习班，每隔一年与p53会议举行一次。第六次这样的讲习班将于2011年10月在纽约州的纽约举行。这次会议由Carol Prives博士(哥伦比亚大学)和James J.Manfredi(西奈山医学院)共同组织。会议地点在曼哈顿市中心的纽约科学院。纽约科学院是一个既定的会议设施。在这项申请中，要求提供资金以支持三个重要的具体目标。第一个目标是便利研究生和博士后研究人员参加第六届国际MDM2讲习班，并加强他们与该领域领导人互动的能力。第二个目标是确保妇女和任职人数不足的少数群体作为受邀发言者出席并参加讲习班。这将由两名受邀发言者参加，他们都是妇女和代表不足的少数群体。第三个目标是加强研究生、博士后研究人员和早期阶段调查人员的出席和参与，他们来自代表人数不足的群体，包括妇女和少数群体。这三个目标的目标将在很大程度上通过明智地使用旅行奖励来实现。国际MDM2研讨会仍然是一个独特的场所，MDM2研究领域的研究人员可以聚集在一起，分享最新的发现，促进合作，并加强试剂交流。这通过确保MDM2调查人员了解这一重要领域的最新研究来刺激科学研究。通过这样做，可以避免重复工作，可以共享陷阱，该领域的知识可以尽可能快地向前发展。 公共卫生相关性：P53肿瘤抑制因子及其负调控因子MDM2癌蛋白已被明确证明在多种人类癌症中发挥重要作用。第六届国际MDM2讲习班将确保加速这一重要领域的研究，并使其对人类疾病产生影响。

DESCRIPTION (provided by applicant): The p53 protein has been well-characterized as playing a tumor suppressor role in human cancer. Indeed, a majority of human tumors have sustained missense mutation in the TP53 gene. Mdm2 is a negative regulator of p53 that has been shown to act by inhibiting the transcriptional activity of p53 via direct binding as well as serving as an E3 ubiquitin ligase to target p53 for degradation. Consistent with such findings, Mdm2 has been implicated as also playing a role in human tumors with its overexpression or gene amplification being observed in a variety of cancers. A p53 Workshop is held every two years to bring together the p53 field in order to report on the latest research and to facilitate collaboration and exchange of reagents. In 2010, the 15th International p53 Workshop was held in Philadelphia, PA. Twelve years ago, a complementing Mdm2 Workshop was organized to be held in alternating years with the p53 conference. The sixth such workshop is to be held in New York, NY in October, 2011. The meeting is being co-organized by Drs. Carol Prives (Columbia University) and James J. Manfredi (Mount Sinai School of Medicine). The site of the conference is at the New York Academy of Sciences in downtown Manhattan. The New York Academy of Sciences is an established meeting facility. In this application, funds are being requested to support three important specific aims. The first aim is to facilitate the attendance of graduate students and postdoctoral researchers at the Sixth International Mdm2 Workshop and enhance their ability to interact with leaders in the field. The second aim is to ensure the attendance and participation of women and underrepresented minorities as invited speakers at the Workshop. This will be accomplished by the participation of two invited speakers who are both women and underrepresented minorities. The third aim is to enhance the attendance and participation of graduate students, postdoctoral researchers, and early-stage investigators who are from underrepresented groups including women and minorities. The goals of the three aims will largely be accomplished through the judicious use of travel awards. The International Mdm2 Workshop continues to be a unique venue in which researchers in the field of Mdm2 research can come together to share recent findings, facilitate collaborations, and enhance exchange of reagents. This stimulates scientific research by ensuring that Mdm2 investigators are aware of the most current research in this significant area. In so doing, duplicate efforts can be avoided, pitfalls can be shared, and knowledge in the field can move forward as rapidly as possible. PUBLIC HEALTH RELEVANCE: The p53 tumor suppressor and its negative regulator the Mdm2 oncoprotein have been clearly shown to play significant roles in a wide variety of human cancers. The Sixth International Mdm2 Workshop will ensure that research in this important field is accelerated and translated to have impact on human disease.