Conference on Aldosterone and ENaC

描述(由申请人提供)：本提案的目的是寻求对APS会议的支持，该会议名为“第七届关于醛固酮和ENaC/Degenerin离子通道家族的国际研讨会：分子机制和病理生理学”，该会议计划在位于加利福尼亚州太平洋格罗夫的历史悠久且与世隔绝的Asilomar会议场地举行。这次会议的一个主要目标是将来自世界各地的临床和基础研究人员聚集在一起，他们对ENaC(和相关的转运体)和醛固酮感兴趣，特别是它们与肾脏和心血管疾病有关，包括高血压。因此，科学主题是临床、基础和转化研究的混合体，使不同的社区能够打破沟通障碍并参与相声，否则这是不可能的。通过关注肾脏和心血管系统中的ENaC和醛固酮，会议提供了一个了解基本和临床问题的窗口，这些问题是人类健康和疾病生物学的基础。会议计划将主要当局的演讲与致力于ENaC和醛固酮研究的年轻研究人员的演讲结合起来。充足的海报会议时间将允许深入讨论，特别专题海报会议将突出学生、研究员和年轻科学家正在进行的研究。会议的目标是：1)聚集在临床、转化和基础研究方面的世界领先者在醛固酮和ENaC及相关领域进行为期数天的密集务虚会，介绍和讨论该领域的最新研究；2)目的2)拥有大量初级研究人员的代表，从研究生(和杰出的本科生)到初级教员；这些初级参与者将介绍他们的新工作，并受益于接触到该领域领导人的研究和思想；第7届国际研讨会的一个新的创新将是该领域领导人为每个主题领域举办的一系列概述讲座。目标3)创造一种环境，使该领域的临床和基础科学家能够交流思想，最好是启动合作，否则就不会发生这种情况；目标4)在初级研究人员中激发对醛固酮-ENaC研究的兴趣，这将影响研究方向，并帮助推动该领域的研究；目标5)通过外联和积极招募代表性不足的人群，促进性别和种族多样性。 与公共卫生相关：关于醛固酮和ENaC的国际研讨会是一个国际会议，每3-4年举行一次，近20年来在北美和欧洲之间轮流举行。来自世界各地的临床和基础研究人员参加了这些会议，他们对ENaC(和相关转运体)和醛固酮感兴趣，特别是因为它们与肾脏和心血管疾病有关，包括高血压。因此，科学主题是临床、基础和转化研究的混合体，使不同的社区能够打破沟通障碍并参与相声，否则这是不可能的。通过关注肾脏和心血管系统中的ENaC和醛固酮，会议提供了一个了解基本和临床问题的窗口，这些问题是人类健康和疾病生物学的基础。这项提议的目的是寻求对定于2011年9月18-22日在加利福尼亚州太平洋格罗夫的Asilomar会议中心举行的题为“醛固酮、ENaC与心血管疾病”的科学研究会议的支持。这次会议由美国生理学会(APS)管理，匹兹堡大学的托马斯·克利曼博士和加州大学旧金山分校的大卫·皮尔斯博士组织。会议的目的是聚集该领域的领导者，讨论他们正在进行的翻译研究以及与ENaC(和相关转运体)和醛固酮主题相关的问题，特别是与肾脏和心血管疾病，包括高血压有关的问题，概述这项工作的未来方向，并建立合作关系，以完成这一未来的研究。

DESCRIPTION (provided by applicant): The purpose of this proposal is to seek support for the APS Conference entitled "7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels: Molecular Mechanisms and Pathophysiology" that is scheduled to take place at the historic and secluded Asilomar Conference Grounds located in Pacific Grove, California. A major goal of this conference will be to bring together clinical and basic researchers from all over the globe with an interest in ENaC (and related transporters) and aldosterone, particularly as they pertain to renal and cardiovascular disorders, including hypertension. Hence, the scientific themes are a blend of clinical, basic and translational research, which allow a diverse community to break down obstacles to communication and engage in crosstalk, which would not otherwise be possible. By focusing on ENaC and aldosterone in the context of the renal and cardiovascular systems, the meeting provides a window into basic and clinical questions, which are fundamental to human biology in health and disease. The conference program combines presentations from leading authorities with presentations from young investigators pursuing research on ENaC and aldosterone. Ample time for poster sessions will allow for in-depth discussions, and special featured poster sessions will highlight ongoing research of students, fellows, and young scientists. The objectives of the conference are: Aim 1) to bring together world leaders in clinical, translational and basic research in aldosterone and ENaC, and related areas for a multi-day intensive retreat to present and discuss the latest research in the field; Aim 2) to have a large representation of junior researchers, from graduate students (and exceptional undergraduates) through postdoctoral researchers to junior faculty; these junior participants will present their new work, and also benefit from exposure to the research and thinking of leaders in the field; a new innovation in for the 7th International Symposium will be a series of overview lectures for each thematic area, given by leaders in the field. Aim 3) create an environment in which clinical and basic scientists in the field can exchange ideas, and ideally initiate collaborations, which would otherwise not occur; Aim 4) engender interest in aldosterone-ENaC research in junior investigators, which will influence research directions, and help move research in the field forward; Aim 5) generate gender and ethnic diversity through outreach and proactive recruitment of underrepresented populations. PUBLIC HEALTH RELEVANCE: The International Symposium on Aldosterone and ENaC is an international meeting, which has been held every 3-4 years, alternating between North America and Europe for almost 20 years. These meetings have been attended by clinical and basic researchers from all over the globe with an interest in ENaC (and related transporters) and aldosterone, particularly as they pertain to renal and cardiovascular disorders, including hypertension. Hence, the scientific themes are a blend of clinical, basic and translational research, which allow a diverse community to break down obstacles to communication and engage in crosstalk, which would not otherwise be possible. By focusing on ENaC and aldosterone in the context of the renal and cardiovascular systems, the meeting provides a window into basic and clinical questions, which are fundamental to human biology in health and disease. The purpose of this proposal is to seek support for a scientific research conference, entitled "Aldosterone, ENaC and Cardiovascular Disease" scheduled for September 18-22, 2011 at the Asilomar Conference Center in Pacific Grove, CA. The conference is managed by the American Physiological Society (APS) and organized by Drs. Thomas Kleyman, University of Pittsburgh, and Dr. David Pearce, University of California, San Francisco. The aim of the meeting is to gather leaders in the field to discuss their ongoing translational research and issues related to the topic of ENaC (and related transporters) and aldosterone, particularly as they pertain to renal and cardiovascular disorders, including hypertension, to outline the future direction of that work, and to establish collaborative relationships to accomplish this future research.