Biennial Symposium of H. ducreyi Pathogenesis and Chancroid

描述（由申请人提供）：杜克雷嗜血杆菌可引起生殖器溃疡性疾病软下疳，在20世纪80年代末之前，它一直被认为是人类疾病的重要原因，直到80年代末，美国发生了数千例软下疳病例，并且发现软下疳是非洲HIV-1异性传播的主要辅助因素。1991年，两年一度的H. ducreyi发病机制和软下疳是与国际性病研究学会（ISSTDR）国际会议同时举行的。会议的目的是促进我们了解这种被忽视的病原体的生物学和流行病学的能力，并制定根除软下疳的战略。螺杆杜克雷伊专题讨论会是国际空间技术减灾战略的一个卫星专题讨论会，每两年举行一次，在北美和欧洲轮流举行。这一具体建议是要求资金，以协助赞助H。ducreyi研讨会，特别是部分承担项目费用和研究生，博士后研究员和年轻教师演讲者参加下三次会议的旅费。第十一届和第十二届国际研讨会将分别在魁北克市和维也纳举行;第十三届会议的地点尚未确定。研讨会的主要目的是提供一个论坛，交流有关软下疳和其他生殖器溃疡疾病的临床和基本方面的信息，并为学生，博士后研究员和新的研究人员提供机会，介绍他们对这种生物体的研究。在连接H. ducreyi研讨会到ISSTDR会议，我们为与会者提供与临床医生，流行病学家，公共卫生人员和在STD研究广泛领域工作的基础科学家进行互动的能力。会议还促进了美国研究人员与软下疳流行的发展中国家研究人员之间的互动。我们的目标是鼓励H. ducreyi和软下疳在发病机理、宿主反应、疫苗开发、新治疗靶点的鉴定、流行病学和疾病控制领域的研究。NIAID Katrin Eichelberg博士的批准函见本申请的PHS 398附信文件附件。 公共卫生相关性：杜克雷嗜血杆菌引起一种名为软下疳的生殖器溃疡疾病，有助于HIV-1的传播。这是一个资金请求，以支持一个国际会议，讨论对H。ducreyi在2011年，2013年和2015年。

DESCRIPTION (provided by applicant): Haemophilus ducreyi, which causes the genital ulcer disease chancroid, was overlooked as a significant cause of human disease until the late1980's, when several thousand cases of chancroid occurred in the United States and chancroid was found to be a major co-factor in the heterosexual transmission of HIV-1 in Africa. In 1991, the first in a series of biennial International Symposia on H. ducreyi Pathogenesis and Chancroid was held in conjunction with the International Society for STD research (ISSTDR) International Meeting. The purpose of the meeting was to promote progress in our ability to understand the biology and epidemiology of this neglected pathogen and to devise strategies to eradicate chancroid. The H. ducreyi symposium is a satellite symposium of the ISSTDR, which meets every two years, alternating between North America and Europe. This specific proposal is to request funds to assist in sponsoring the H. ducreyi symposium, specifically to partially underwrite program costs and the expense of travel of graduate students, postdoctoral fellows, and young faculty presenters to the next three iterations of the meeting. The 11th and 12th International Symposia will be held in Quebec City and Vienna respectively; the venue for the 13th meeting has not been determined. The major objective of the Symposium is to provide a forum for exchange of information on clinical and basic aspects of chancroid and other agents of genital ulcer disease, and to provide the opportunity for students, post-doctoral fellows and new investigators to present their research on this organism. In connecting the H. ducreyi symposium to the ISSTDR meeting, we provide participants the ability to interact with clinicians, epidemiologists, public health personnel and basic scientists who work in the broad area of STD research. The meeting also fosters interaction between investigators from the United States with those from developing countries where chancroid is endemic. Our goal is to encourage basic and clinical research in the biology of H. ducreyi and chancroid in the areas of pathogenesis, host responses, vaccine development, identification of novel therapeutic targets, epidemiology, and disease control. An approval letter from Dr. Katrin Eichelberg from the NIAID can be found in the PHS398 Cover Letter File attachment of this application. PUBLIC HEALTH RELEVANCE: Haemophilus ducreyi causes a genital ulcer disease called chancroid, which facilitates HIV-1 transmission. This is a request for funds to support an international meeting to discuss research on H. ducreyi in 2011, 2013 and 2015.