Gordon Research Conference and Gordon-Kenan Research Seminar on Matrix Metallopro

描述(由申请人提供)：关于基质金属蛋白酶的戈登研究会议(GRC)旨在为来自不同学科的科学家和医生提供一个论坛，以报告最新的研究结果并讨论这些具有医学意义的蛋白酶的新概念。会议还包括对ADAMTS和ADAM金属蛋白酶的研究，以促进关于这些密切相关的金属蛋白酶的思想和概念的交流。MMPGRC自1993年以来每两年举行一次，出席人数踊跃，并取得了相当大的成功，实现了其目标，即按照GRC组织的传统，为尖端金属蛋白酶研究提供一个主要论坛。2011年MMPGRC将于2011年8月在国际扶轮布莱恩特大学举行，将继续努力成为MMPs和相关蛋白的首要会议。为此，我们计划将来自不同学科的领军研究人员和初级研究人员聚集在一起，围绕会议的新主题《基础科学和应用医学交汇处的新兴基质金属蛋白酶研究》，介绍和讨论他们最新的金属蛋白酶研究。本主题的主要目的是将金属蛋白酶结构和功能的基本分子和细胞机制的最新进展整合到成功的临床应用中。为了实现这一目标，我们计划开发一个一流的创新科学计划，重点讨论最近从细胞和动物模型以及系统生物学、化学、蛋白质组学和基因组学技术进步中出现的疾病条件下金属蛋白酶功能的范例。该项目将包括该领域知名调查人员、职业生涯早期的独立调查人员和新调查人员的陈述。在这次会议的历史上，第一次将由对金属蛋白酶研究感兴趣的博士后研究员和研究生组织关于MMPs的Gordon-Kenan研究研讨会(GRS)。GRS将为年轻的研究人员提供一个独特而令人兴奋的论坛，展示他们的研究并发现GRC的经验。GRS期间的活动将旨在：(1)为初级研究人员提供机会，学习和讨论MMPs在疾病中常见机制和作用的基本背景，以最大限度地了解将在随后的GRC中讨论的科学；(2)从该领域的同行和专家那里获得关于他们正在进行的研究项目的反馈，并与他们讨论他们的想法；以及(3)促进他们与这个科学界的高级成员的互动，以促进他们的专业发展。我们完全预期，2011年的科学讨论、研究讲座、海报会议和与会者之间的其他非正式互动将延续这些独特的会议的传统，即促进我们对金属蛋白酶功能的理解，将这一知识转化为人类疾病的新的治疗干预措施。 与公共健康相关：成立于1993年的关于基质金属蛋白酶的戈登研究会议是金属蛋白酶领域最负盛名的科学会议，金属蛋白酶是一组参与许多人类疾病发病机制的酶。会议提供了一个论坛，展示尖端金属蛋白酶研究的最新进展，并教育对该领域感兴趣的新一代年轻研究人员。预计这次会议传统上具有特色的合作和合作气氛将为人类疾病的智力开发和实施新疗法提供完美的环境，涉及解除调节的金属蛋白酶活性。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on Matrix Metalloproteases (MMP) is designed to provide scientists and physicians from a wide range of disciplines with a forum to report the latest research findings and discuss new concepts on these medically relevant proteases. The conference also covers research on ADAMTS and ADAM metalloproteases to enable cross-fertilization of ideas and concepts on these closely related metalloproteinases. The MMP GRC has been held every two years since 1993 with a robust attendance and considerable success in accomplishing its goal of providing a premier forum for cutting-edge metalloproteinase research, in the tradition of the GRC organization. The 2011 MMP GRC, which will be held in August 2011 at Bryant University, RI, will continue to strive to be premier conference on MMPs and related proteases. To this end, we plan to bring together leading investigators and junior investigators from a variety of disciplines to present and discuss their latest metalloproteinase research around the new theme of the conference: "Emerging MMP Research at the Intersection of Basic Science and Applied Medicine." The main of objective of this theme is to integrate recent advances in basic molecular and cellular mechanisms of metalloproteinase structure and function into successful clinical applications. To achieve this objective, we plan to develop a first-rate and innovative scientific program that focuses on discussing recent paradigms on metalloproteinase function in disease conditions that are emerging from cellular and animal models and technological advances in system biology, chemistry, proteomics, and genomics. The program will include presentations from prominent investigators in the field, early-career independent investigators and new investigators. For the first time in the history of this conference, a Gordon-Kenan Research Seminar (GRS) on MMPs will be organized by postdoctoral fellows and graduate students with interest in metalloproteinase research. The GRS will provide a unique and exciting forum for young researchers to present their research and discover the GRC experience. Activities during the GRS will be oriented to: (1) provide junior investigators with the opportunity to learn and discuss basic background on common mechanisms and role of MMPs in disease to maximize their understanding of the science which will be discussed in the subsequent GRC, (2) receive feedback on their ongoing research projects from and discuss their ideas with peers and experts in the field, and (3) facilitate their interaction with senior members of this scientific community to promote their professional development. We fully anticipate that the scientific discussions, research talks, poster sessions, and other informal interactions between the participants at the 2011 and future MMP GRCs and GRSs will continue with the tradition of these unique conferences of advancing our understanding of metalloproteinase function towards the translation of this knowledge into novel therapeutic interventions in human diseases. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Matrix Metalloproteinases established in 1993 is the most prestigious scientific conference in the field of metalloproteinases, a group of enzymes involved in the pathogenesis of many human diseases. The conference provides a forum to present the latest advances in cutting-edge metalloproteinase research and to educate the new generation of young investigators interested in the field. It is anticipated that the collegial and cooperative atmosphere that has traditionally characterized this conference will provide the perfect setting for the intellectual development and implementation of novel therapeutics in human diseases involving deregulated metalloproteinase activity.