2011 Molecular Pharmacology GRC and GRS

描述（由申请人提供）：分子药理学侧重于药物在分子水平上的作用机制。药物作为临床诊断和治疗药物的使用，以及在生理学和疾病机制的研究，使分子药理学成为实验生物学和医学中非常活跃的学科。分子药理学是一门界面学科，它整合了分子生物学、细胞生物学和结构生物学、基因组学、化学和系统生物学等领域的方法。分子药理学的研究旨在阐明药物作用的基本方面，并提供新的药理工具和治疗方法。此外，临床医学的进步对药物作用的分子基础提出了新的问题。分子药理学处于实验生物学和转化研究的交叉点，使其成为一个令人兴奋的发现领域，旨在为与临床医学相关的问题提供答案。这些想法是NIH支持2011年分子药理学戈登研究会议（GRC）的基础，该会议旨在整合基础研究和转化研究，并强调细胞系统和动物模型中药物受体的分子机制和病理生理方面的最新进展。本次GRC的主题将包括癌症、感染、心血管和内分泌疾病中的信号和药物作用，以及与行为、成瘾药物和多器官系统调节有关的关键分子方面的不断发展的信息。

DESCRIPTION (provided by applicant): Molecular Pharmacology focuses on the mechanisms of drug action at a molecular level. The use of drugs as clinical diagnostic and therapeutic agents and in studying mechanisms in physiology and disease makes molecular pharmacology a very dynamic discipline in experimental biology and medicine. Molecular pharmacology is an interface discipline that integrates approaches from fields that include molecular, cellular and structural biology, genomics, chemistry and systems biology. Research in molecular pharmacology seeks to elucidate fundamental aspects of drug action and provide new pharmacological tools and therapies. In addition, progress in clinical medicine has raised new questions regarding the molecular basis of drug action. The placement of molecular pharmacology at the interface of experimental biology and translational research makes it an exciting area of discovery that seeks to provide answers to questions of relevance to clinical medicine. These ideas underlie this application for NIH support for the 2011 Molecular Pharmacology Gordon Research Conference (GRC), which seeks to integrate basic and translational research and to highlight recent advances regarding molecular mechanisms and pathophysiological aspects of drug receptors in cell systems and animal models. Topics at this GRC will be in areas that include signaling and drug action in cancer, infection, cardiovascular and endocrine disorders as well as evolving information regarding critical molecular aspects that contribute to behavior, drugs of addiction and the regulation of multiple organ systems. PUBLIC HEALTH RELEVANCE: Beyond its role in updating information within the field, the Molecular Pharmacology GRC contributes to the training and creative development of the next generation of scientists who will drive the field forward. The intimate, informal atmosphere of the conference gives trainees (e.g., graduate students and post-doctoral fellows) an opportunity to experience the excitement of cutting-edge research and to interact with senior scientists.