PUERTO RICO CLINICAL AND TRANSCRIPTIONAL RESEARCH CONSORTIUM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 描述（由申请人提供）：迫切需要减少或消除影响服务不足的少数民族人口的许多健康差距。尽管在了解疾病的基本机制方面取得了重大进展，但将这些知识转化为治疗和预防疾病的工作一直有限而缓慢，特别是对这些得不到充分服务的少数民族和种族而言。将建立波多黎各临床和转化研究联盟（PRCTRC），作为推进知识转化并对这些差异产生影响的概念。这将是一个集中的临床和转化研究计划，重点关注服务不足的少数民族人口中普遍存在的健康问题，并在波多黎各的三个主要学术卫生保健机构之间建立多学科和协作努力。主要计划目标是：1）加强和整合现有的临床和转化研究基础设施，以支持和扩大健康差异的临床和转化研究; 2）加强和支持现有的培训和指导计划，以增加临床和转化研究中新的少数民族研究者的数量; 3）促进知识从实验室到社区的翻译。为了实现这些目标，我们将整合，扩展和增强：1）参与者和临床互动资源2）生物统计学和数据管理的临床和转化研究核心资源3）核心实验室和技术4）培训和发展计划5）支持法规遵从性资源6）信息资源7）社区互动和参与计划。拟议的计划将是综合性的，整合所有三个机构的资源和领导，其中许多在RCMI临床研究中心（RCMI-CRC）和健康差异综合中心（CCHD）下，但在一个单一的行政结构下融合。拟议的方案将是包容性的，包括各级行政责任的所有参与机构的领导。它将是新颖的，因为它将提供一个独特的机会，整合资源，并在一个主要由少数民族人口组成的国家规模的领土上产生影响。 公共卫生相关性（由申请人提供）：拟议的计划将有助于促进对不成比例地影响少数民族人口的条件的了解，并将为服务于这些人口的机构之间更有效的合作提供平台。通过加强和巩固现有资源，它将促进在以患者为导向的研究中发现新知识，并将有助于发展新的临床和翻译少数民族研究人员。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): There is an urgent need for reducing or eliminating many health disparities that affect underserved minority populations. Despite important advances in knowledge about the basic mechanisms of disease, translation of this knowledge to treatment and prevention of disease has been limited and slow, in particular for these underserved ethnic and racial minorities. The Puerto Rico Clinical and Translational Research Consortium (PRCTRC) will be established as the concept that will advance this translation of knowledge and have an impact on these disparities. It will be a centralized clinical and translational research program focused on health problems prevalent in an underserved minority population and establishing a multidisciplinary and collaborative effort between three major academic health care institutions in Puerto Rico. The major programmatic goals are to: 1) To enhance and integrate existing infrastructure for clinical and translational research to support and expand Clinical and Translational Research in the Health Disparities; 2) To enhance and support existing training and mentoring programs to increase the number of new minority investigators in Clinical and Translational Research; 3) To facilitate the translation of knowledge from the bench into the community. To accomplish these goals we will integrate, expand and enhance: 1) Participant and Clinical Interaction Resources 2) Clinical and Translational Research core resources in Biostatistics and Data Management 3) Core laboratories and technologies 4) Training and developmental programs 5) Support for regulatory compliance resources 6) Informatic resources 7) Community interactions and participation programs. The proposed program will be integrative, incorporating resources and leadership from all three institutions, many of these under the RCMI-Clinical Research Center (RCMI-CRC) and the Comprehensive Center for Health Disparities (CCHD) but fusing under a single administrative structure. The proposed program will be inclusive, incorporating leadership from all the participating institutions at several levels of administrative responsibility. It will be novel, because it will provide a unique opportunity to incorporate resources and have an impact across a state-size territory composed primarily of a minority population. PUBLIC HEALTH RELEVANCE (provided by applicant): The proposed program will help advance knowledge about conditions that disproportionately affect minority populations and will provide a platform for more efficient collaborations among institutions that serve these populations. By enhancing and consolidating existing resources it will facilitate the discovery of new knowledge in patient-oriented research and will aid in the development of new, clinical and translational minority researchers.