Tumor Immunology Training Program

描述(申请人提供)：这份T32申请在H.Lee Moffitt癌症中心的肿瘤免疫学培训计划的目标是培训博士后研究员进入癌症的翻译免疫学和免疫疗法领域。18名教职员工由同等数量的基础科学家和临床研究人员组成，他们有共同解决与肿瘤免疫有关的问题的历史。他们共同组成了一个团队，研究肿瘤免疫学的三个主要领域：1)先天免疫，2)获得性免疫，3)癌症免疫治疗。这些方法是分子的，定义了与NK细胞、树突状细胞、髓系细胞、干细胞和T细胞有关的信号分子和基因调控成分。根据实验室的发现，还识别了癌症患者中T细胞可以识别的抗原，并寻找了克服免疫耐受的方法。这种环境为培训博士后研究员进行床到床研究以及床边到床上的工作提供了理想的环境。我们要求每年新增2名博士后研究员，连续资助三年，到第三年将总共获得6名博士后研究员。 由Julie Djeu博士领导的教育委员会将监督培训，其中包括来自这三个研究领域的每个领域的一名教职员工。它包括一个结构化的项目，包括导师/学员对的正式研究建议，以及对进展的定期评估和职业发展计划。除了实验室研究，学员还将参加正在进行的研究研讨会，参加外部演讲者的基础和临床大讨论，并参加与他们的研究相关的适当课程。那些更接近翻译重点的人将拥有基本的和临床导师，并将接触到医院的患者，包括临床查房。还将获得有关IRBs、INDS和人类安全等监管问题的经验。癌症中心最先进的核心设施还将提供许多领域的宝贵培训经验，包括蛋白质组学、基因组学、流式细胞术、分析显微镜。这种深入的培训将使博士后研究员成为学术界或工业界分子和翻译免疫学方面的成功研究人员。

DESCRIPTION (provided by applicant): This T32 application for a Tumor Immunology Training Program at the H. Lee Moffitt Cancer Center has the goal of training postdoctoral fellows to enter the field of translational immunology and immunotherapy of cancer. The eighteen faculty members comprise of an equal number of basic scientists and clinical investigators who have a history of working together in solving problems related to tumor immunity. Together, they form a team that addresses 3 major areas of tumor immunology 1) innate immunity, 2) adaptive immunity, and 3) immunotherapy of cancer. The approaches have been molecular, defining the signal molecules and gene regulatory components that are involved in NK cells, dendritic cells, myeloid cells, stem cells, and T cells. Antigens that can be recognized by T cells in cancer patients are also identified and means to overcome immune tolerance are sought out, based on findings in the laboratory. This environment provides an ideal setting for training of postdoctoral fellows in bench-to-bedside research as well as bedside- to-bench work. We request 2 new postdoctoral fellows, at the Ph.D. level, per year, with consecutive funding for three years, resulting in 6 total fellows by the third year. An Educational Committee, headed by Dr. Julie Djeu, with a faculty member from each of the 3 areas of research, will oversee the training. It involves a structured program with a formal research proposal from the mentor/mentee pair and regular evaluations of progress and a plan for career development. In addition to laboratory research, trainees will participate in Research-in-Progress Seminars, attend Basic and Clinical Grand Round from outside speakers, and take appropriate classes pertaining to their research. Those closer to a translational focus will have a basic as well as a clinical mentor, and will have exposure to patients in the hospital including Clinical Rounds. Experience with regulatory issues such as IRBs, INDs, and Human Safety will also be gained. State-of-the-art Core Facilities at the Cancer Center will also providing valuable training experience in numerous areas including proteomics, genomics, flow cytometry, analytical microscopy. This in-depth training will allow the postdoctoral fellow to become a successful researcher in molecular and translational immunology in academia or industry.