Integrated Endocrine and Metabolic Research Training

描述(由申请人提供)：贝丝以色列女执事医学中心的内分泌培训项目，由芭芭拉·卡恩博士指导，每年培训四名内分泌学、糖尿病和新陈代谢研究领域的医学博士、医学博士/博士或博士后研究员。该计划的目标是将受训人员培养成独立的调查人员，他们将在科学调查方面出类拔萃，并能够在主要大学医学院获得教职。内分泌项目的研究人员是一群经验丰富的研究人员，他们参与了肥胖症、糖尿病、甲状腺生物学、核受体作用、神经内分泌学和信号转导的研究。该学院由基础和临床科学家组成，他们共同努力培训研究员在分子和生理层面上研究问题。作为波士顿地区NIH资助的肥胖中心和糖尿病内分泌研究中心的一部分，这些教师的多个联合出版物、他们的三个项目项目补助金以及他们的多个研究核心设施都表明了他们的合作性质。正在开始博士后工作或更高级的受训者有机会向教师在激素作用、基因表达、脂肪细胞生物学、动物生理学、内分泌和代谢障碍的先进转基因和基因靶向方法、神经解剖学和神经生理学、人体研究以及新治疗方式的战略方面的综合和集体专业知识学习。学员由T32提供1-3年的支持。他们在获得独立资金方面有着出色的记录，许多以前的实习生已经被提升到教员职位。这些资助的研究人员现在参加内分泌学、糖尿病和新陈代谢方面的这一项目和其他项目的培训研究员。自上次竞争性续期以来，该司增加了新的有才华的教员，并扩大了其研究空间和核心设施。该计划得到了贝丝以色列女执事医疗中心在基因组学、蛋白质组学、质谱学、生物统计学和生物信息学以及转基因小鼠世代的核心设施的大力支持。该项目进一步将负责任和道德的研究行为课程正规化。学员的成功反映了这一内分泌培训计划的卓越质量。 公共卫生相关性：目前肥胖和糖尿病的流行席卷美国民众，这增加了对训练有素的学术内分泌学家的需求，他们可以通过临床、翻译和基础科学方法来解决这一问题。贝丝以色列女执事医疗中心的内分泌培训计划在培养这样的科学家方面取得了长期的成就。代谢性疾病的浪潮有增无减，突显了继续开展这一培训计划的重要活动的重要性。

DESCRIPTION (provided by applicant): The Endocrine Training Program at Beth Israel Deaconess Medical Center, directed by Dr. Barbara Kahn, trains four MD, MD/PhD or PhD postdoctoral fellows per year in the research areas of endocrinology, diabetes, and metabolism. The goal of the program is to foster the development of trainees into independent investigators who will excel in scientific investigation and can obtain faculty positions at major university medical schools. The research faculty for the endocrine program is an experienced group of investigators involved in the study of obesity, diabetes, thyroid biology, nuclear receptor action, neuroendocrinology, and signal transduction. The faculty is comprised of basic and clinical scientists who work together to train fellows to investigate questions at both the molecular and physiological levels. The collaborative nature of the faculty is made evident by their multiple joint publications, their three Program Project Grants and their multiple research core facilities as part of Boston area NIH-funded Obesity Centers and Diabetes Endocrinology Research Centers. Trainees who are either beginning their postdoctoral work or are more advanced are provided an opportunity to learn from the integrated and collective expertise of the faculty in hormone action, gene expression, adipocyte biology, animal physiology, sophisticated transgenic and gene targeting approaches to endocrine and metabolic disorders, neuroanatomy and neurophysiology, research in human subjects, and strategies for novel treatment modalities. Trainees are supported by the T32 for 1-3 years. They have an outstanding record of obtaining independent funding and a number of former trainees have been promoted to faculty positions. These funded investigators now participate themselves in training fellows in this and other Programs in Endocrinology, Diabetes and Metabolism. Since the last competitive renewal of this grant, the Division has added new, talented faculty and expanded its research space and core facilities. The program is strongly supported by core facilities at Beth Israel Deaconess Medical Center in Genomics, Proteomics, Mass Spectrometry, Biostatistics and Bioinformatics, and Transgenic Mouse Generation. The program has further formalized its curriculum in the responsible and ethical conduct of research. The success of the trainees reflects the outstanding quality of this Endocrine Training Program. PUBLIC HEALTH RELEVANCE: The current epidemic of obesity and diabetes sweeping the American populace has heightened the need for well-trained academic endocrinologists who can address the problem with clinical, translational, and basic science approaches. The Endocrine Training Program at the Beth Israel Deaconess Medical Center has a long record of accomplishment in turning out such scientists. The undiminished tide of metabolic disease underscores the importance of continuing the vital activities of this Training Program.