BIOSTATISTICS CORE

该核心资源将提供全面的生物统计学和生物信息学咨询与合作 约翰霍普金斯头颈部孢子的所有项目。此外，它还将支持 数据存储、信息学和计算，并协助识别和解决复杂数据 项目活动过程中产生的任务。核心成员将与项目调查人员合作， 广泛的活动，包括数据采集（包括研究设计，目标的可行性， 公共获取基因组信息的可用性和数据存储），统计质量控制（包括 伪像检测和基因组技术数据的预处理），数据分析（包括 可视化，生物统计建模，并协助手稿写作），并开发创新的 根据具体项目的需要定制生物统计和生物信息学方法和工具。的 拟议的头颈部孢子生物统计学核心将设在临床试验司， 肿瘤学系的生物统计学，生物统计学和生物信息学的一个积极和致力于小组 教师，获得国家的最先进的设备和广泛的专业知识。这一核心 资源是原始和当前头颈部孢子内现有资源的延续 约翰霍普金斯的一个项目。核心成员对这个SPORE有坚定的承诺，源于：a）a 与本项目以及其他SPORE项目的研究人员合作的历史，B）一个积极的， 独立供资的协同项目议程，以及c）表现出对 生物学和分析学的问题和挑战。预计所有拟议项目将使 利用这一资源。

This Core resource will provide comprehensive biostatistics and bioinformatics consultation and collaboration to all projects in the proposed Johns Hopkins Head and Neck SPORE. In addition, it will provide support for data storage, informatics, and computing, and assist with the identification and solution of complex data tasks arising in the course of project activities. Core members will work with project investigators across a wide spectrum of activities, encompassing data acquisition (including study design, feasibility of objectives, availability of public-access genomic information, and data storage), statistical quality control (including artifact detection and preprocessing of data from genomic technologies), data analysis (including visualization, biostatistical modeling, and assistance with manuscript writing), and development of innovative customized biostatistics and bioinformatics methodologies and tools if required by specific projects. The proposed Head and Neck SPORE Biostatistics Core will be housed in the Division of Clinical Trials and Biometry of the Department of Oncology, an active and committed group of biostatistics and bioinformatics faculty members, with access to state-of-the art equipment and a broad range of expertise. This Core resource is the continuation of an existing resource within the original and current Head and Neck SPORE program at Johns Hopkins. Core members have a strong commitment to this SPORE, stemming from: a) a history of collaboration with the investigators of this as well as other SPORE projects, b) an active and independently funded agenda of synergistic projects, and c) a demonstrated interest and understanding of both the biological and analytical questions and challenges. All proposed projects are anticipated to make use of this resource.