BIOSTATISTICS CORE

这一核心资源将提供全面的生物统计和生物信息学咨询与协作 约翰·霍普金斯大学头颈部孢子计划中的所有项目。此外，它还将为 数据存储、信息学和计算，并协助识别和解决复杂数据 在项目活动过程中产生的任务。核心成员将与项目调查人员在 广泛的活动，包括数据采集(包括研究设计、目标的可行性、 可供公众获取的基因组信息和数据存储)、统计质量控制(包括 人工产物检测和来自基因组技术的数据的预处理)、数据分析(包括 可视化、生物统计建模和帮助撰写手稿)，以及开发创新的 如果特定项目需要，定制生物统计学和生物信息学方法和工具。这个 拟议的头和颈部孢子生物统计核心将设在临床试验和 肿瘤学系的生物计量学，一个积极和致力于生物统计学和生物信息学的团体 拥有先进的设备和广泛的专业知识的教职员工。此核心 资源是指原始和当前头颈部孢子内现有资源的延续 约翰斯·霍普金斯大学的项目。核心成员对这一孢子有强烈的承诺，源于：a)a) 与这一项目以及其他孢子项目的调查人员合作的历史，b)积极和 独立资助的协同项目议程，以及c)表现出的兴趣和了解 包括生物学和分析方面的问题和挑战。所有拟议的项目预计都将使 这一资源的使用。

This Core resource will provide comprehensive biostatistics and bioinformatics consultation and collaboration to all projects in the proposed Johns Hopkins Head and Neck SPORE. In addition, it will provide support for data storage, informatics, and computing, and assist with the identification and solution of complex data tasks arising in the course of project activities. Core members will work with project investigators across a wide spectrum of activities, encompassing data acquisition (including study design, feasibility of objectives, availability of public-access genomic information, and data storage), statistical quality control (including artifact detection and preprocessing of data from genomic technologies), data analysis (including visualization, biostatistical modeling, and assistance with manuscript writing), and development of innovative customized biostatistics and bioinformatics methodologies and tools if required by specific projects. The proposed Head and Neck SPORE Biostatistics Core will be housed in the Division of Clinical Trials and Biometry of the Department of Oncology, an active and committed group of biostatistics and bioinformatics faculty members, with access to state-of-the art equipment and a broad range of expertise. This Core resource is the continuation of an existing resource within the original and current Head and Neck SPORE program at Johns Hopkins. Core members have a strong commitment to this SPORE, stemming from: a) a history of collaboration with the investigators of this as well as other SPORE projects, b) an active and independently funded agenda of synergistic projects, and c) a demonstrated interest and understanding of both the biological and analytical questions and challenges. All proposed projects are anticipated to make use of this resource.