CORTICAL-SUBCORTICAL INTERACTION IN PARKINSON'S DISEASE AND NORMAL SPEECH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 使用丘脑下核（sub-thalamic nucleus，DBS）的深部脑刺激（deep brain stimulation，DBS）治疗帕金森病（Parkinson’s disease，PD）提供了一种改变皮层下区域活动的可逆手段。虽然有效地减少非言语运动症状，这种形式的治疗往往没有效果，甚至对语言的负面影响，提出了关于PD的语言和非语言运动控制之间的关系的问题。使用功能成像和可量化的语音生产任务，该项目提出了研究与PD受试者的皮质和皮质下区域的大脑活动之间的关系，在与DBS治疗的PD受试者，并在正常对照组。 我们的目标是更好地了解正常和紊乱的语音中的皮层和皮层下的相互作用，以及这种相互作用在语音产生的特定方面的作用。 区域脑血流量将测量在几个语音生产任务，使用正电子发射断层扫描，以解决四个主要的具体目标。 第一个主要的具体目标集中在正常受试者在语音产生过程中皮层和皮层下区域之间的关系。 第二个主要的具体目标集中在皮层和皮层下区域之间的关系，在PD受试者的语音生产。 第三个主要的具体目标集中在言语产生过程中的皮质和皮质下区域之间的关系与双侧丘脑下核DBS治疗的PD受试者。 第四个主要的具体目标是检查和比较言语产生的具体特征和局部脑血流量之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The use of deep brain stimulation (DBS) of the sub thalamic nuclei (STN) to treat Parkinson's disease (PD) provides a reversible means of modifying the activity of sub cortical areas. While effective in reducing non speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non speech motor control in PD. Using functional imaging and quantifiable speech production tasks, this project proposes to study the relationships between brain activity in cortical and subcortical regions in subjects with PD, in subjects with PD treated by DBS, and in normal controls. The goal is to better understand cortical subcortical interactions in normal and disordered speech, and the role of such interactions in specific aspects of speech production. Regional cerebral blood flow will be measured during several speech production tasks using positron emission tomography to address four primary specific aims. The first primary specific aim focuses on the relationships between cortical and subcortical areas during speech production in normal subjects. The second primary specific aim focuses on the relationships between cortical and subcortical areas during speech production in PD subjects. The third primary specific aim focuses on the relationships between cortical and subcortical areas during speech production in PD subjects treated with bilateral DBS of the sub-thalamic nuclei. The fourth primary specific aim is to examine and compare the relationships between specific characteristics of speech production and regional cerebral blood flow.