CARDIAC RESYNCHRONIZATION THERAPY AND THE SKELETAL MYOPATHY OF HEART FAILURE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 1.1 CRT是否能长期减少晚期HF患者的静息MSNA？ 1.2 CRT后MSNA降低的HF患者的骨骼肌病变是否逆转？ 1.3动脉压力感受器和心肺感受器增益的增加是否是CRT后MSNA降低的基础？ 1.4 HF患者增强的肌肉机械感受器敏感性的逆转是否有助于CRT后MSNA的降低？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1.1 Does CRT reduce resting MSNA chronically in advanced HF? 1.2 Is the skeletal myopathy reversed in HF patients in whom MSNA is decreased following CRT? 1.3 Does an increase in arterial baroreceptor and cardiopulmonary receptor gain underlie this decrease in MSNA following CRT? 1.4 Does reversal of the augmented muscle mechanoreceptor sensitivity in HF contribute to the decrease in MSNA following CRT?