DOES ENDOGENOUS ADENOSINE SENSITIZE MUSCLE MECHANORECEPTOR CONTROL OF MUSCLE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with heart failure compared to people without heart failure have exaggerated increases in sympathetic nerve activity during exercise, which may contribute to exercise intolerance, shortness of breath, and fluid retention. The purpose of this study is to determine if, by blocking the effects of compounds released by your body during arm exercise with aminophylline, the increase in sympathetic nerve activity will be blocked as well. Aminophylline is a FDA-approved drug for asthma. However, it is not approved for use in the treatment of heart failure or its symptoms. We hope that this research will help us understand why patient with heart failure cannot exercise very much.