DOES ENDOGENOUS ADENOSINE SENSITIZE MUSCLE MECHANORECEPTOR CONTROL OF MUSCLE

内源性腺苷是否使肌肉机械感受器对肌肉的控制变得敏感

• 批准号: 7606745
• 负责人: HOLLY R MIDDLEKAUFF
• 金额: $ 0.48万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-21 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606745
• 关键词: Adenosine; Aminophylline; Asthma; Computer Retrieval of Information on Scientific Projects Database; Exercise; Funding; Grant; Heart failure; Institution; Liquid substance; Mechanoreceptors; Muscle; Nerve; Patients; Pharmaceutical Preparations; Purpose; Research; Research Personnel; Resources; Shortness of Breath; Source; Symptoms; United States National Institutes of Health; Upper arm

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with heart failure compared to people without heart failure have exaggerated increases in sympathetic nerve activity during exercise, which may contribute to exercise intolerance, shortness of breath, and fluid retention. The purpose of this study is to determine if, by blocking the effects of compounds released by your body during arm exercise with aminophylline, the increase in sympathetic nerve activity will be blocked as well. Aminophylline is a FDA-approved drug for asthma. However, it is not approved for use in the treatment of heart failure or its symptoms. We hope that this research will help us understand why patient with heart failure cannot exercise very much.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 与没有心力衰竭的人相比，心力衰竭患者在运动期间交感神经活动过度增加，这可能导致运动不耐受、呼吸急促和液体潴留。 这项研究的目的是确定，如果通过使用氨茶碱阻断手臂运动期间身体释放的化合物的作用，交感神经活动的增加也会被阻断。 氨茶碱是FDA批准的治疗哮喘的药物。 然而，它没有被批准用于治疗心力衰竭或其症状。 我们希望这项研究能帮助我们理解为什么心力衰竭患者不能经常运动。