Epidemiology of oral gamma and beta HPV infections in mid-adult women

项目描述 口腔或口咽部的人乳头瘤病毒（HPV）感染导致约25%的头颈部 癌症（主要是口咽）。HPV阳性口咽癌的数量预计将超过 到2020年宫颈癌的发病率。考虑到HPV在口咽癌中的作用， 口腔HPV感染的流行病学和自然史是突出的。然而，目前这类数据有限， 并且几乎仅限于生殖器（α）HPV类型。现有研究表明，口腔HPV 在健康人群中的患病率很低，但可能低估了HPV感染的真实患病率。 口腔由于限制α HPV类型。最近，已在100名女性中检测到β和γ HPV类型。 健康男性和HIV阳性男性和女性的口腔，表明更广泛的嗜性， 这些HPV基因。据我们所知，还没有研究过γ型和β型HPV的存在 健康女性的口腔样本也没有关于伽马的性行为决定因素的数据 或口腔中的β感染。此外，虽然γ和β HPV的手口途径 传播是假设的，但从未被探索过。该提案涉及以下疾病的流行病学： 在409名30至50岁的健康女性中进行口腔γ和β HPV感染。我们建议 有效地利用储存的样本（包括口腔和指甲尖样本），以达到以下目的：1） 估计口腔γ和β HPV感染的患病率; 2）确定口腔 和指甲尖样本，用于检测伽马和β HPV类型;以及3）识别健康和性行为 决定因素的口服伽玛和β HPV感染。我们的研究也有可能发现新的 口腔HPV类型这项探索性研究的结果可以为更大规模的开发提供信息。 对口腔中γ和β HPV感染的流行病学和自然史研究，特别是 我们对这些属在口腔肿瘤发生中的作用的认识不断提高。此外，我们的研究结果将进一步 我们对HPV嗜性的理解，有可能有助于我们对HPV相关的 传播和感染的生物学和机制。

Project Description Human papillomavirus (HPV) infections of the oral cavity or oropharynx cause about 25% of head and neck cancers (mainly oropharyngeal). The number of HPV-positive oropharyngeal cancers is expected to exceed that of cervical cancers by 2020. Given the role of HPV in oropharyngeal cancers, understanding the epidemiology and natural history of oral HPV infections is salient. Currently, however, such data are limited, and have been restricted almost exclusively to genital (alpha) HPV types. Extant studies suggest that oral HPV prevalence in healthy individuals is low, but likely underestimate the true prevalence of HPV infection in the oral cavity due to restriction to alpha HPV types. Recently, beta and gamma HPV types have been detected in the oral cavity of healthy men and HIV-positive men and women, suggesting a broader spectrum of tropism for these HPV genera. To our knowledge, the presence of gamma and beta HPV types has not been investigated in oral cavity samples from healthy women. There are also no data on sexual behavior determinants of gamma or beta infections in the oral cavity. Furthermore, while a hand-to-mouth route for gamma and beta HPV transmission has been postulated, it has never been explored. This proposal addresses the epidemiology of oral gamma and beta HPV infections among 409 healthy women, aged 30 to 50 years old. We propose to make efficient use of stored samples (including oral and fingernail tip samples) to address the following aims: 1) Estimate the prevalence of oral gamma and beta HPV infections; 2) Determine the concordance between oral and fingernail tip samples for detecting gamma and beta HPV types; and 3) Identify health and sexual behavior determinants of oral gamma and beta HPV infections. Our study also has the potential to identify novel oncogenic oral HPV types. The results of this exploratory study could inform the development of larger epidemiologic and natural history studies of gamma and beta HPV infections in the oral cavity, particularly as our knowledge of the role of these genera in oral tumorigenesis advances. Furthermore, our results will further our understanding of HPV tropism, with potential to contribute to our general understanding of HPV-related biology and mechanisms of transmission and infection.