Statistical Methods for Mendelian Randomization

这是一个新发起的研究项目。 在传统的流行病学研究中，表型(危险因素)与疾病之间的联系往往因混淆和反向因果关系而产生偏差。由于一个人的基因型是由一个看似随机的过程分配的，基因可能是调整这种偏见的有用工具变量。这种类型的调整结合了关于基因型别疾病关联和基因类型C表型关联的信息，以估计表型C疾病关联，并已成为众所周知的孟德尔随机化。 该项目旨在为孟德尔随机化开发各种有效的统计方法，从研究设计、建模和估计。

This is a newly initiated research project. In traditional epidemiological studies the association between phenotype (risk factor) and disease is often biased by confounding and reverse causation. As a persons genotype is assigned by a seemingly random process, genes are potentially useful instrumental variables for adjusting for such bias. This type of adjustment combines information on the genotypeCdisease association and the genotypeCphenotype association to estimate the phenotypeCdisease association and has become known as Mendelian randomization. This project aims at developing various efficient statistical methods for Mendelian Randomiztion, ranging from study design, modeling and estimation.