Biostatistics Core

在美国和发达国家，结直肠癌是第三种最常见的癌症，也是与癌症相关的死亡的第二大原因。尽管有被证明有效的预防性筛查工具，但在高危年龄组(50岁以上)中，只有不到50%的平均风险美国人进行了筛查。年龄过后，结肠和/或息肉的个人和家族病史是最常见的危险因素。随着APC突变，腺瘤的形成和发展的机制被证明是复杂的。4个项目的综合办法从几个不同的角度处理这些问题。生物统计学核心(核心D)为所有犹他大学结肠癌PPG项目、核心、调查人员和参与者提供统计专业知识。核心成员在1)实验室和临床研究研究的设计、实施和分析方面进行合作，以及2)开发和应用新的统计方法和分析算法以解决与PPG项目相关的问题。核心员工将作为研究团队的协作成员，共同制定设计和分析计划，以解决研究问题。生物统计核心提供的职能包括制定实验设计、参与研究实施、数据质量监测、统计分析和结果解释，以及就结果的提出进行合作。为了实现这些职能，核心主任和生物统计学家与项目调查人员合作，并与项目和核心领导保持定期联系。生物统计核心的主要目标是1)提供所有实验室、动物和临床研究的研究设计和审查，包括可行性评估、功率分析和样本量 计算。2)在项目数据分析、结果解释以及最终研究报告和手稿的撰写方面进行合作。3)在活动中与分析核心(核心B)和临床核心(核心C)合作，以确保数据质量和及时捕获数据。4)根据PPG项目的要求，开发和评估试验设计和数据分析的统计方法。 生物统计核心支持犹他大学的所有四个结肠癌PPG项目。

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths in the United States and the developed world. Despite the availability of proven effective preventive screening tools, less than 50% of average risk Americans in the high-risk age group (over 50) have been screened. After age, personal and family history of colon and/or polyps is the most common risk factor. Following APC mutation, the mechanisms of adenoma formation and progression are proving complex. The integrated approach of the 4 projects addresses these issues from several different perspectives. The Biostatistics Core (Core D) provides statistical expertise for all University of Utah Colon Cancer PPG projects, cores, investigators and participants. Core members collaborate in 1) the design, implementation, and analysis of laboratory and clinical research studies, and 2) the development and application of new statistical methods and analysis algorithms to address problems relevant to PPG projects. Core staff will function as collaborative members of research teams to jointly develop design and analysis plans to address research questions. Functions provided by the Biostatistics Core include development of experimental designs, participation in study implementation, data quality monitoring, statistical analysis and interpretation of findings, and collaboration on presentation of results. To achieve these functions, the Core director and biostatisticians collaborate with project investigators, and are in regular contact with the project and core leaders. The primary objectives of the Biostatistics Core are 1) To provide study design and review of all laboratory, animal and clinical studies including feasibility assessment, power analysis and sample size calculation. 2) To collaborate in projects' data analysis, interpretation of results, and the writing of final study reports and manuscripts. 3) To work with the Analytical Core (Core B) and Clinical Core (Core C) in their activities to ensure data quality and timely data capture. 4) To develop and evaluate statistical methods for experimental design and data analysis as required for PPG projects. The Biostatistics Core supports all four Colon Cancer PPG projects at the University of Utah.